지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 임윤경
- 발행연도
- 2017
- 저작권
- 대전대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Objective : The purpose of this study was to investigate the effects of Hyangsayangwi-tang intravenous herbal acupuncture (HYT-IVHA) on emesis and gastric hypomotility induced by chemotherapy in rats.
Methods : The experimental animals were allocated into six groups (normal, cisplatin, saline, HYT-1, HYT-2, HYT-3), and each group included five rats. The rats in the normal group did not receive any treatment. Those in the cisplatin group had no additional treatment after intraperitoneal injection of cisplatin (7㎎ / ㎏). Those in the saline group were injected with saline 0.4㎖ via the tail vein after the injection of cisplatin. Those in the HYT-1 group, HYT-2 group, HYT-3 group were injected with 0.4㎖ of Hyangsayangwi-tang intravenous herbal acupuncture solution (HYT-IVHAS) via tail vein, and the concentrations were 0.199g/kg, 0.066g/kg, 0.022g/kg respectively.
Then we measured body weight, food intake, kaolin consumption before and 12h, 24h, 36h after the injection of cisplatin. The remaining amount of food within the rat’s stomach was also measured 36h after cisplatin injection.
Results : Kaolin consumption was significantly increased in the cisplatin group and saline group compared to the normal group, while significantly reduced in HYT-1, HYT-2, HYT-3 groups compared to the cisplatin group. The remaining amount of food in stomach was significantly increased in the cisplatin group, saline group, and HYT-1 group compared to the normal group, but significantly reduced in the HYT-3 group compared to the cisplatin group and saline group.
Conclusions : These results suggest that HYT-IVHA has an therapeutic effect on chemotherapy-induced emesis and gastric hypomotility.
Methods : The experimental animals were allocated into six groups (normal, cisplatin, saline, HYT-1, HYT-2, HYT-3), and each group included five rats. The rats in the normal group did not receive any treatment. Those in the cisplatin group had no additional treatment after intraperitoneal injection of cisplatin (7㎎ / ㎏). Those in the saline group were injected with saline 0.4㎖ via the tail vein after the injection of cisplatin. Those in the HYT-1 group, HYT-2 group, HYT-3 group were injected with 0.4㎖ of Hyangsayangwi-tang intravenous herbal acupuncture solution (HYT-IVHAS) via tail vein, and the concentrations were 0.199g/kg, 0.066g/kg, 0.022g/kg respectively.
Then we measured body weight, food intake, kaolin consumption before and 12h, 24h, 36h after the injection of cisplatin. The remaining amount of food within the rat’s stomach was also measured 36h after cisplatin injection.
Results : Kaolin consumption was significantly increased in the cisplatin group and saline group compared to the normal group, while significantly reduced in HYT-1, HYT-2, HYT-3 groups compared to the cisplatin group. The remaining amount of food in stomach was significantly increased in the cisplatin group, saline group, and HYT-1 group compared to the normal group, but significantly reduced in the HYT-3 group compared to the cisplatin group and saline group.
Conclusions : These results suggest that HYT-IVHA has an therapeutic effect on chemotherapy-induced emesis and gastric hypomotility.
목차
제1장 서 론 1제2장 실 험 31. 동물 32. Kaolin 33. 약침액 제조 34. 실험군 55. Saline 주입 및 혈맥약침 시술 56. 데이터 측정 56.1 몸무게 56.2 사료 섭취량 56.3 Kaolin 섭취량 66.4 위 내 음식 잔여량 측정 67. 통계 분석 6제3장 결 과 71. 몸무게 변화량 72. 사료 섭취량 83. Kaolin 섭취량 104. 위 내 음식 잔여량 12제4장 고 찰 13제5장 결 론 17참 고 문 헌 18ABSTRACT 22
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