지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 정노희
- 발행연도
- 2016
- 저작권
- 충북대학교 논문은 저작권에 의해 보호받습니다.
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Cationic surfactants are widely used in many industries. They are used as detergent, emulsifier, softner and antimicrobial agent.
In this study, benzyltrialkylammoniumchlorides with different alkyl chain length were synthesized and applied to liposome. Structure of synthesized cationic surfactants was investigated by FT-IR and 1H-NMR. Prepared cationic surfactant embedded liposomes were measured particle size, zetapotential, release property and antibacterial activity. The average particle size of liposomes was 120~140 nm. As alkyl chain length was increased, the liposome size was increased. Zetapotential for the solution of liposomes added cationic surfactants were in the range of +80~90 mV. Hydrophilic collagen release rate was related to hydrophobic alkyl chain length.
In release test, liposome embedded long alkyl chain surfactant had enhanced sustained release property. Also, collagen release rate could be controlled by alkyl chain length.
Entrapment efficiency of hydrophilic collagen were 25.9~27.5%. This results shows that entrapment efficiency of hydrophilic materials not related to alkyl chain length in contrast with hydrophobic materials.
In this study, benzyltrialkylammoniumchlorides with different alkyl chain length were synthesized and applied to liposome. Structure of synthesized cationic surfactants was investigated by FT-IR and 1H-NMR. Prepared cationic surfactant embedded liposomes were measured particle size, zetapotential, release property and antibacterial activity. The average particle size of liposomes was 120~140 nm. As alkyl chain length was increased, the liposome size was increased. Zetapotential for the solution of liposomes added cationic surfactants were in the range of +80~90 mV. Hydrophilic collagen release rate was related to hydrophobic alkyl chain length.
In release test, liposome embedded long alkyl chain surfactant had enhanced sustained release property. Also, collagen release rate could be controlled by alkyl chain length.
Entrapment efficiency of hydrophilic collagen were 25.9~27.5%. This results shows that entrapment efficiency of hydrophilic materials not related to alkyl chain length in contrast with hydrophobic materials.
목차
Ⅰ. 서론 1Ⅱ. 실험 5Ⅱ-1. 재료 및 장치 5Ⅱ-2. Benzyltrialkylammoniumchloride의 합성 6Ⅱ-3. Benzyltrialkylammoniumchloride의 분석 6Ⅱ-4. Benzyltrialkylammoniumchloride을 첨가한 리포좀의 제조 8Ⅱ-5. 리포좀의 특성 분석 10Ⅲ. 결과 및 고찰 12Ⅲ-1. Benzyltrialkylammoniumchloride의 합성 결과 12Ⅲ-1-1. Benzyltrialkylammoniumchloride의 구조분석 12Ⅲ-1-2. HLB 산정 17Ⅲ-2. 리포좀의 분석 17Ⅲ-2-1. 리포좀의 항균성 18Ⅲ-2-2. 리포좀의 평균 입도분포 18Ⅲ-2-3. 리포좀의 분산 안정성 22Ⅲ-2-4. 리포좀의 포집효율 25Ⅲ-2-5. 리포좀의 방출특성 27Ⅳ. 결 론 29참고문헌 30
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