지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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CONTENTSChapter 11. Introduction1.1 Introduction 31.2 Metabolism of drugs 41.3 Analysis of metabolites 71.4 The purpose of this study 10Chapter 22. Experiment2.1 Chemicals and reagents 112.2 Instruments 122.3 Experiment methods 132.3.1 Sample preparation 132.3.1.1 Urine sampling 132.3.1.2 Purification 132.3.1.3 Hydrolysis 142.3.1.4 Extraction 152.3.1.5 Derivatization 162.3.2 Validation of Experimental methods 222.3.3 Analysis of 5-androsten-3β-,17β-diol-7-one diacetate and its metabolites using LC/TOF-MS 232.3.4 Analysis of 5-androsten-3β-,17β-diol-7-one diacetate and its metabolites using GC/MSD 23Chapter 33. Results3.1 Separation and extraction of 5-androsten-3β-,17β-diol-7-one diacetate in urine sample 253.1.1 The optimal extraction conditions for metabolites of 5-androsten-3β-,17β-diol-7-one in urine sample 253.1.2 The optimal derivatization conditions of 5-androsten-3β-,17β-diol-7-one metabolites from urine sample 273.1.3 Validation of analysis procedures 303.2 Analysis of 5-androsten-3β-,17β-diol-7-one diacetate and its endogenous metabolites by LC/MS 323.2.1 Identification of M1-5-androsten-3β, 7α, 17β -triol in urine sample 373.2.2 Identification of M2-5-androsten-3β, 17β?diol-7-one in urine sample 373.2.3 Identification of M3-5-androsten-3β, 16α, 17β?triol-7-one in urine sample 383.3 Analysis of 5-androsten-3β-,17β-diol-7-one diacetate and its endogenous metabolites by GC/MSD 383.3.1 Identification of M1-5-androsten-3β, 7α, 17β-triol in urine sample 393.3.2 Identification of M2-5-androsten-3β, 17β?diol-7-one in urine sample 403.3.3 Identification of M3-5-androsten-3β, 16α, 17β?triol-7-one in urine sample 413.4 Investigation of excretion of chemical species using endogenous metabolites of 5-androsten-3,17β-diol-7-one-diacetate 483.5 Investigation of excretion tendencies of metabolites of 5-androsten-3β, 17β?diol-7-one diacetate 50Chapter 44. Conclusion 52References 53
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