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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 발행연도
- 2016
- 저작권
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초록· 키워드
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Pyrazolopyrimidine, pyrazolopyridine and thienopyrimidine derivatives as central core have been recently investigated due to their biological and chemotherapeutic importance such as anticancer activity, aintimicrobial activity and anti-inflammatory activity.
In this study, new pyrazolo[3,4-b]pyrimidinylthienopyrimidine and pyrazolo-
[3,4-b]pyridinylthienopyrimidine were designed and synthesized by integrating pyrazolopyrimidine or pyrazolopyridine into the thienopyrimidine core.
Novel 4-(3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thienopyrimidine derivatives were successfully synthesized by the reaction of 3-phenyl-1-
(thienopyrimidin-4-yl)-1H-pyrazol-5-amine with a novel Vilsmeier agents using formamide and POCl3. And, 3,4,6-triphenyl-1-(thienopyrimidin-4-yl)-
1H-pyrazolo[3,4-b]pyridine-5-carbonitrile were also efficiently synthesized from the one-pot reaction of 3-phenyl-1-(thienopyrimidin-4-yl)-1H-pyrazol-
5-amine, benzaldeyde derivatives and benzoylacetonitrile as a multi-component reactions (MCRs).
In this study, new pyrazolo[3,4-b]pyrimidinylthienopyrimidine and pyrazolo-
[3,4-b]pyridinylthienopyrimidine were designed and synthesized by integrating pyrazolopyrimidine or pyrazolopyridine into the thienopyrimidine core.
Novel 4-(3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thienopyrimidine derivatives were successfully synthesized by the reaction of 3-phenyl-1-
(thienopyrimidin-4-yl)-1H-pyrazol-5-amine with a novel Vilsmeier agents using formamide and POCl3. And, 3,4,6-triphenyl-1-(thienopyrimidin-4-yl)-
1H-pyrazolo[3,4-b]pyridine-5-carbonitrile were also efficiently synthesized from the one-pot reaction of 3-phenyl-1-(thienopyrimidin-4-yl)-1H-pyrazol-
5-amine, benzaldeyde derivatives and benzoylacetonitrile as a multi-component reactions (MCRs).
목차
Ⅰ. 서 론 1Ⅱ. 결과 및 고찰 61. 4-(1H-Pyrazolo[3,4-d]pyrimidin-1-yl)thienopyrimidine유도체의 합성 61-1. 4-(3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thieno[2,3-d]pyrimidine유도체의합성성 6(1). 4-Hydrazinylthieno[2,3-d]pyrimidine 유도체의 합성 6(2). 3-Phenyl-1-(thieno[2,3-d]pyrimidin-4-yl)-1H-pyrazol-5-amine유도체의 합성 8(3). 4-(3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thieno[2,3-d]pyrimidine 유도체의 합성 111-2. 4-(3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thieno[3,2-d]pyrimidine 유도체의 합성 14(1). 4-Hydrazinylthieno[3,2-d]pyrimidine의 합성 14(2). 3-Phenyl-1-(thieno[3,2-d]pyrimidin-4-yl)-1H-pyrazol-5-amine 유도체의 합성 16(3). 4-(3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)thieno[3,2-d]pyrimidine 유도체의 합성 182. 4-(1H-Pyrazolo[3,4-b]pyridin-1-yl)thienopyrimidine 유도체의 합성 202-1. 3,4,6-Triphenyl-1-(thieno[2,3-d]pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile유도체의 합성 202-2. 3,4,6-Triphenyl-1-(thieno[3,2-d]pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile유도체의 합성 22Ⅲ. 결 론 25Ⅳ. 실험 결과 26Ⅴ. 참고 문헌 43Ⅵ. 부 록 44
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