Titanium (Ti) is useful tool in clinical medicine and dentistry due to have excellent mechanical properties, high corrosion resistance, and biocompatibility. Recently, Ti has focused on the development of surface-releasing systems because surface modifications can enhance the osseointegration with alveolar bone, which can be used as useful dental implants. However, most approaches performed that based on the solvent coating method, which has several drawbacks, including the use of organic solvents and low interfacial adhesion between the coating and the medical device surface. Thus, more simple and effective research are needed. In this study, we designed a chitosan nanoparticle-immobilized Ti surface that can release simvastatin (SV) in a controlled manner. Our specific approach was the pre-treatment of Ti surface with dopamine coatings, followed by chitosan nanoparticle immobilization. The SV-loaded nanoparticles were prepared by self-assembly of 5β-cholanic acid-conjugated glycol chitosan in the presence of SV. Dynamic light scattering and TEM analyses showed the SV-loaded nanoparticles that hydrodynamic diameter of 383.0 nm and a spherical shape. An immobilization of the SV-loaded nanoparticles onto dopamine-treated Ti surfaces could be achieved by a simple dipping method in an aqueous solution. The successful immobilization of nanoparticles onto Ti surfaces was confirmed by FE-SEM and the SV releasing test performed for up to 20 days. As a results, the advantage of this system is that the nanoparticles can be prepared possible so that tailored to release a variety of bioactive materials. Thus, we suggest that SV-loaded nanoparticles immobilized onto Ti may serve for various medical devices in bone-regenerative field.