지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 이현
- 발행연도
- 2014
- 저작권
- 대전대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Objective :
This study was designed to evaluate the effects of Tokoro Rhizoma herbal acupuncture(TR-HA) at KI10 in nephritis induced by lipopolysaccharide(LPS) in rat.
Methods :
Rats were divided into 4 groups and 3 groups(LPS, Saline, TR-HA group) were injected LPS to induce nephritis. TR-HA group was treated with TR-HA at KI10 three times for a week, Saline group with normal saline. To evaluate the effects of TR-HA at KI10 on nephritis in rats, WBC, neutrophil in blood, creatinine, CINC-1 in serum and urinary volume, creatinine in urine, renal MPO were measured and renal tissue was analyzed.
Results :
TR-HA group significantly reduced WBC, neutrophil in blood, creatinine, CINC-1 in serum, creatinine in urine and renal MPO than LPS group. TR-HA group increased urinary volume but, not significant.
Conclusion :
TR-HA at KI10 has a therapeutic effect on nephritis in LPS stimulated rat. Therefore, it is suggested that TR-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
This study was designed to evaluate the effects of Tokoro Rhizoma herbal acupuncture(TR-HA) at KI10 in nephritis induced by lipopolysaccharide(LPS) in rat.
Methods :
Rats were divided into 4 groups and 3 groups(LPS, Saline, TR-HA group) were injected LPS to induce nephritis. TR-HA group was treated with TR-HA at KI10 three times for a week, Saline group with normal saline. To evaluate the effects of TR-HA at KI10 on nephritis in rats, WBC, neutrophil in blood, creatinine, CINC-1 in serum and urinary volume, creatinine in urine, renal MPO were measured and renal tissue was analyzed.
Results :
TR-HA group significantly reduced WBC, neutrophil in blood, creatinine, CINC-1 in serum, creatinine in urine and renal MPO than LPS group. TR-HA group increased urinary volume but, not significant.
Conclusion :
TR-HA at KI10 has a therapeutic effect on nephritis in LPS stimulated rat. Therefore, it is suggested that TR-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
목차
Ⅰ. 서 론 3Ⅱ. 실 험 51. 재 료 51) 동물 52) 약재 53) 시약 및 기기 6(1) 시약 6(2) 기기 62. 방 법 71) 약침액의 제조 72) 세포독성 9(1) 간세포 분리 9(2) MTT assay 93) 신장염 동물 모델 94) 실험군 분류 및 처치 105) 결과 분석 10(1) 혈액 분석 10(2) 소변 분석 11(3) 신장 내 염증활성 평가 11(4) 통계분석 11Ⅲ. 성 적 121. 세포독성 122. LPS투여에 따른 TNF-alpha의 농도 변화 131) Serum TNF-alpha 132) Renal TNF-alpha 143. 비해 약침이 LPS에 의한 rat의 신장염에 미치는 영향 151) 혈액학적 분석 15(1) WBC 16(2) Neutrophil 172) Blood chemistry 18(1) Creatinine 19(2) CINC-1(Cytokine-induced neutrophil chemoattractant-1) 203) 소변 분석 21(1) 이뇨 활성 22(2) Creatinine 234) 신장 내 염증활성 24(1) MPO(myeloperoxidase) 25Ⅳ. 고 찰 26Ⅴ. 결 론 31Ⅵ. 참고문헌 32Abstract 36
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