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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 안영민
- 발행연도
- 2014
- 저작권
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Objective : Type 2 diabetes mellitus is a metabolic disorder that is characterized by a high glucose level in the context of insulin resistance and relative insulin deficiency. Obesity accelerates the development of insulin resistance and type 2 diabetes mellitus. This study was designed to examine the effects of Crataegus Fructus on obese type 2 diabetes mice.
Methods : Type 2 diabetes mellitus and obesity were induced by Surwit''s high fat, high sucrose diet. Mice were divided into 4 groups of ND(normal diet, n=10), HFD(high fat and high sucrose diet, n=10), Met(high fat and high sucrose diet with Metformin, n=10) and CP(high fat and high sucrose diet with Crataegus Fructus, n=10). The body weights were measured every week. After 7 weeks FBS and OGTT were measured, and after 8 weeks liver profile, lipid level, leptin concentration, epididiymal fat pad and liver weight, adipokine(TNF-?, IL-6), white adipocyte size, and adipose tissue macrophage(ATM) were determined.
Results : Compared with the HFD group, body weight, FBS, OGTT, fructosamine, leptin, epididymal fat pad weight, white adipocyte size, TNF-?, and ATM were significantly reduced, whereas HDL cholesterol was increased in the CP group.
Conclusions : These findings suggest that Crataegus Fructus may have anti-diabetic and anti-obesity effects through the regulation of glucose and lipid levels, as well as by reducing inflammation. Therefore, Crataegus Fructus may be effective in patients with type 2 diabetes mellitus.
Methods : Type 2 diabetes mellitus and obesity were induced by Surwit''s high fat, high sucrose diet. Mice were divided into 4 groups of ND(normal diet, n=10), HFD(high fat and high sucrose diet, n=10), Met(high fat and high sucrose diet with Metformin, n=10) and CP(high fat and high sucrose diet with Crataegus Fructus, n=10). The body weights were measured every week. After 7 weeks FBS and OGTT were measured, and after 8 weeks liver profile, lipid level, leptin concentration, epididiymal fat pad and liver weight, adipokine(TNF-?, IL-6), white adipocyte size, and adipose tissue macrophage(ATM) were determined.
Results : Compared with the HFD group, body weight, FBS, OGTT, fructosamine, leptin, epididymal fat pad weight, white adipocyte size, TNF-?, and ATM were significantly reduced, whereas HDL cholesterol was increased in the CP group.
Conclusions : These findings suggest that Crataegus Fructus may have anti-diabetic and anti-obesity effects through the regulation of glucose and lipid levels, as well as by reducing inflammation. Therefore, Crataegus Fructus may be effective in patients with type 2 diabetes mellitus.
목차
Ⅰ. 서 론 1Ⅱ. 실험 방법 31. 검체 제조 32. 고지방 고탄수화물 식이 유발 비만형 제2형 당뇨병 동물 모델의 제작 33. 실험군 배정 및 연구 계획 44. 체중 측정 55. 경구 당부하 검사(OGTT ; oral glucose tolerance test) 측정 56. 지질 및 당대사 분석 57. 혈청 leptin 측정 68. 지방 및 간 무게 측정 69. 지방세포 크기 측정 610. 지방조직에서의 RNA 분리 711. 지방세포의 TNF-, IL-6 유전자의 발현 측정 712. Stromal vascular cell의 분리 813. Adipose tissue macrophages(ATMs)에 대한 Fluorescence activated cell sorting(FACS) 분석 914. 통계 분석 9Ⅲ. 결과 101. 체중에 미치는 영향 및 사료섭취량 102. 당대사에 미치는 영향 123. 혈장 지질농도 및 leptin 농도에 미치는 영향 154. 지방 및 간 무게에 미치는 영향 185. 부고환 지방세포 크기에 미치는 영향 206. 지방세포의 TNF-, IL-6에 미치는 영향 227. Adipose tissue macrophages(ATMs)에 미치는 영향 24Ⅳ. 고 찰 27Ⅴ. 결 론 33참 고 문 헌 34ABSTRACT 42
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