지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 이광호
- 발행연도
- 2014
- 저작권
- 상지대학교 논문은 저작권에 의해 보호받습니다.
이용수0
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Abstract
Effects of Paljeong-san Pharmacopuncture on Experimental Rat Model of Benign Prostatic Hyperplasia
Chae-Weon Kim
Dept. of Acupuncture & Moxibustion Medicine
Graduate School of Korean Medicine
Sangji University, Wonju, Gangwon, Korea
(Directed by Prof. Kwang-Ho Lee, K.M.D., Ph.D.)
Objectives:
The aim of this study is to evaluate the effect of Paljeong-san pharmacopuncture (PJS) on the rat model of benign prostatic hyperplasia (BPH).
Methods:
Rats were divided into 5 groups, with 6 rats in each group. The 5 groups included sham-operated group (Sham), BPH model group (BPH), finasteride-treated group (Fina), PJS-treated groups (PJS10 and PJS100). Testosterone was injected subcutaneously to the castrated rats except sham group for BPH model. During 4-week experimental period, Finasteride (5 mg/kg) was administrated orally once daily in Fina group, PJS in PJS10 (10 ㎎/㎏) and PJS100 (100 ㎎/㎏) group and normal saline in sham and BPH group were injected subcutaneously once daily in Zhongwan (CV12).
We checked prostate weights, serum concentration of DHT, morphologic change of the prostate, and the amount of expression of the PCNA and 5α-reductase gene to evaluate the effect of PJS.
Results:
Comparing with BPH group, PJS-treated groups showed no significant changes in prostate weights, but showed significant degreases concentration-dependently in the amount of expression of the PCNA and 5α-reductase gene. PJS treatment also showed shrinking of thickness in the prostatic epithelial tissue.
Conclusions:
PJS has the effects that improve the symptoms of BPH through inhibiting proliferation of the prostatic tissues.
Key words: benign prostatic hyperplasia, paljeong-san, pharmacopuncture, finasteride
Effects of Paljeong-san Pharmacopuncture on Experimental Rat Model of Benign Prostatic Hyperplasia
Chae-Weon Kim
Dept. of Acupuncture & Moxibustion Medicine
Graduate School of Korean Medicine
Sangji University, Wonju, Gangwon, Korea
(Directed by Prof. Kwang-Ho Lee, K.M.D., Ph.D.)
Objectives:
The aim of this study is to evaluate the effect of Paljeong-san pharmacopuncture (PJS) on the rat model of benign prostatic hyperplasia (BPH).
Methods:
Rats were divided into 5 groups, with 6 rats in each group. The 5 groups included sham-operated group (Sham), BPH model group (BPH), finasteride-treated group (Fina), PJS-treated groups (PJS10 and PJS100). Testosterone was injected subcutaneously to the castrated rats except sham group for BPH model. During 4-week experimental period, Finasteride (5 mg/kg) was administrated orally once daily in Fina group, PJS in PJS10 (10 ㎎/㎏) and PJS100 (100 ㎎/㎏) group and normal saline in sham and BPH group were injected subcutaneously once daily in Zhongwan (CV12).
We checked prostate weights, serum concentration of DHT, morphologic change of the prostate, and the amount of expression of the PCNA and 5α-reductase gene to evaluate the effect of PJS.
Results:
Comparing with BPH group, PJS-treated groups showed no significant changes in prostate weights, but showed significant degreases concentration-dependently in the amount of expression of the PCNA and 5α-reductase gene. PJS treatment also showed shrinking of thickness in the prostatic epithelial tissue.
Conclusions:
PJS has the effects that improve the symptoms of BPH through inhibiting proliferation of the prostatic tissues.
Key words: benign prostatic hyperplasia, paljeong-san, pharmacopuncture, finasteride
목차
등록된 정보가 없습니다.
최근 본 자료
댓글(0)
0