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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 임성우
- 발행연도
- 2014
- 저작권
- 동국대학교 논문은 저작권에 의해 보호받습니다.
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Objectives : This study was carried out to investigate the Mitigating effect of Yukmijihwang-tang on antral gastritis and duodenitis by regulating gastrin release in mice.
Methods : The normal group was mice with no inflammation. The control group was mice with gastroduodenal-inflammation elicited by ethanol. The sample group was mice administered Yukmijihwang-tang after gastroduodenal-inflammation elicitation. This study examined the morphological change of gastric mucosa and intestinal villi, and the change of the immunohistochemical distribution of Gastrin, Substance P, HSP70, NF-κB p65, iNOS. ANOVA test was performed at the p<0.05 level of significance.
Results : In the common morphology and histochemical change, various injury - mucous surface cell, micro-villi, absorptive cell, paneth cell - by hemorrhagic erosion were observed in the control group, while they were significantly decreased in the sample group. In the immunohistochemical change, the distributions of gastrin, substance P, HSP70, NF-κB p65, iNOS in the group treated with Yukmijihwang-tang were noticeably lower than in the control group (p<0.05).
Conclusions : According to the above results, it is supposed that Yukmijihwang-tang had significant mitigating effect on antral gastritis and duodenitis in mice.
Methods : The normal group was mice with no inflammation. The control group was mice with gastroduodenal-inflammation elicited by ethanol. The sample group was mice administered Yukmijihwang-tang after gastroduodenal-inflammation elicitation. This study examined the morphological change of gastric mucosa and intestinal villi, and the change of the immunohistochemical distribution of Gastrin, Substance P, HSP70, NF-κB p65, iNOS. ANOVA test was performed at the p<0.05 level of significance.
Results : In the common morphology and histochemical change, various injury - mucous surface cell, micro-villi, absorptive cell, paneth cell - by hemorrhagic erosion were observed in the control group, while they were significantly decreased in the sample group. In the immunohistochemical change, the distributions of gastrin, substance P, HSP70, NF-κB p65, iNOS in the group treated with Yukmijihwang-tang were noticeably lower than in the control group (p<0.05).
Conclusions : According to the above results, it is supposed that Yukmijihwang-tang had significant mitigating effect on antral gastritis and duodenitis in mice.
목차
Ⅰ. 서 론 1Ⅱ. 실 험 31. 실험재료 31.1 실험동물 31.2. 六味地黃湯의 제조 32. 실험 방법 42.1. 날문위염과 십이지장염 유발 42.2. 六味地黃湯 투여 42.3. 조직표본제작 42.4. GDJ내 위산분비와 연동운동 인자 변화 관찰 42.5. 날문위염 변화 관찰 52.5.1. 중성점액분비세포의 분포 변화 관찰 52.5.2. Substance P 생성 변화 52.6. 십이지장염 변화 관찰 52.6.1. 융모 (villi) 변화 관찰 52.6.2. 점막 손상 스트레스 변화 관찰 62.6.3. NF-κB 활성 변화 관찰 62.6.4. iNOS 생성 변화 관찰 62.7. 영상분석과 통계처리 6Ⅲ. 결 과 71. GDJ내 Gastrin 분비 조절 72. 날문위염 완화 효과 92.1. GDJ내 출혈성 찰과 억제 92.2. 점액분비세포 보호 효과 92.3. Substance P 생성 조절 효과 93. 십이지장염 완화 효과 123.1. 융모 손상 완화 123.2. 점막 손상 스트레스 완화 123.3. NF-κB 활성 억제 123.4. 염증효소 iNOS 분포 변화 13Ⅳ. 고 찰 16Ⅴ. 결 론 21참 고 문 헌 22ABSTRACT 25
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