지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 정노희.
- 발행연도
- 2013
- 저작권
- 충북대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
오류제보하기
Collagen is protein that composed of animal''s bone, cartilage and skin and fish''s scales. There is consist of amino acid such as proline, oxyproline, glycine and glutamic acid. And, collagen has an effect on moisture rising, anti-aging, ultraviolet block effect and hair loss prevention. But collagen of animal has low absorbed into the body. Liposome is skin-friendly, stability, less toxic and biodegradability because of spherical vesicles composed of a lipid bilayer. It can be encapsulated both water soluble and insoluble. In this study, liposome has been prepared by solvent extraction method. To increase the absorption of collagen for skin, used fish collagen and has applied liposome technology. To improve membrane solidity, was used ethanol and propylene glycol.. Liposome is influenced by preparation method, collagen contents, temperature, solvent and cholesterol contents. Optimal collagen liposome was prepared by variable condition changes.
Particle size and shape of prepared liposome was confirmed by Dynamic Light Scattering(DLS), Polarized Optical Microscopes(POM), Scanning Electron Microscope(SEM).
The optimal prepared condition of liposome was determined in this study. Liposome was small particle size of 288 nm at condition such as 0.001 wt% of collagen contents, 65 ℃ of temperature and 10% of cholesterol.
Particle size and shape of prepared liposome was confirmed by Dynamic Light Scattering(DLS), Polarized Optical Microscopes(POM), Scanning Electron Microscope(SEM).
The optimal prepared condition of liposome was determined in this study. Liposome was small particle size of 288 nm at condition such as 0.001 wt% of collagen contents, 65 ℃ of temperature and 10% of cholesterol.
목차
Ⅰ. 서 론 1Ⅱ. 실 험 4Ⅱ-1. 실험재료 4Ⅱ-2. 실험장치 5Ⅱ-3. 리포좀의 제조 5Ⅱ-4. 기기 분석 9Ⅲ. 결과 및 고찰 11Ⅲ-1. 리포좀의 제조 11Ⅲ-2. 기기 분석 11Ⅲ-2-1. 평균입자크기 및 입도분포 11Ⅲ-2-1-1. 콜라겐 함량에 따른 영향 11Ⅲ-2-1-2. 온도 변화에 따른 영향 13Ⅲ-2-1-3. 용매 변화에 따른 영향 16Ⅲ-2-1-4. 콜레스테롤 함량에 따른 영향 20Ⅲ-2-2. 편광현미경 23Ⅲ-2-3. 주사전자현미경 25Ⅳ. 결 론 27참고문헌 29
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