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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 김재수
- 발행연도
- 2013
- 저작권
- 대구한의대학교 논문은 저작권에 의해 보호받습니다.
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We investigated the anti-obesity effect of Eugenia caryophyllata Thunb in mice fed a high fat diet. Male ICR mice were divided into three groups, which were fed a normal AIN diet (N), a high fat diet (CT), a high fat diet and injected with 50 mg/kg of Eugenia caryophyllata Thunb pharmacupuncture (EC) for 8 weeks.
1. The levels of body weight gains were significantly increased in CT compared with N and decreased in EC compared with CT.
2. The levels of absolute liver weight and adipose-tissue weight were significantly decreased in EC compared with CT. The levels of relative adipose-tissue weight were significantly decreased in EC compared with CT.
3. The levels of ALT and AST were shown there were no significant differences in all groups. The levels of TG, TC, HDL cholesterol and LDL cholesterol were significantly increased in CT compared with N and decreased in EC compared with CT. The levels of HDL/LDL ratio were shown there were no significant differences in all groups.
4. The levels of adiponectin in serum were remarkably decreased in CT compared with N and significantly increased in EC compared with CT.
5. The levels of leptin in serum were shown there were no significant differences in all groups.
6. The levels of measuring adipocyte number in adipose tissue was significantly decreased in CT compared with N and increased in EC compared with CT.
These results suggest that Eugenia Caryophyllata Thunb has an anti-obesity effect in mice and that the effect is mediated by inhibition of fat gain.
1. The levels of body weight gains were significantly increased in CT compared with N and decreased in EC compared with CT.
2. The levels of absolute liver weight and adipose-tissue weight were significantly decreased in EC compared with CT. The levels of relative adipose-tissue weight were significantly decreased in EC compared with CT.
3. The levels of ALT and AST were shown there were no significant differences in all groups. The levels of TG, TC, HDL cholesterol and LDL cholesterol were significantly increased in CT compared with N and decreased in EC compared with CT. The levels of HDL/LDL ratio were shown there were no significant differences in all groups.
4. The levels of adiponectin in serum were remarkably decreased in CT compared with N and significantly increased in EC compared with CT.
5. The levels of leptin in serum were shown there were no significant differences in all groups.
6. The levels of measuring adipocyte number in adipose tissue was significantly decreased in CT compared with N and increased in EC compared with CT.
These results suggest that Eugenia Caryophyllata Thunb has an anti-obesity effect in mice and that the effect is mediated by inhibition of fat gain.
목차
Ⅰ. 서 론 1Ⅱ. 재료 및 방법 31. 실험재료 32. 실험동물 33. 간 및 지방 무게 측정 44. 혈액생화학적 지표분석 55. 지방조직의 형태적인 관찰 56. ELISA assay 57. 자료분석 및 통계처리 7Ⅲ. 결 과 81. 사료섭취량 82. 체중 변화 93. 간 및 지방 무게 분석 104. 혈액 생화학적 분석 13가. 혈청 내 AST 함량 분석 13나. 혈청 내 ALT 함량 분석 14다. 혈청 내 Triglyceride 함량 분석 15라. 혈청 내 total cholesterol 함량 분석 16마. 혈청 내 High density lipoprotein 17바. 혈청 내 Low density lipoprotein 18사. 혈청 내 HDL/LDL ratio 분석 19아. 혈청 내 glucose 함량 분석 205. ELISA assay 21가. 혈청 내 Adiponectin 함량 분석 21나. 혈청 내 leptin 함량 분석 226. 조직학적 분석 23Ⅳ. 고 찰 26Ⅴ. 결 론 33참 고 문 헌 34Abstract 40
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