지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 유영
- 발행연도
- 2013
- 저작권
- 고려대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Background: Thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of the serum TARC and MDC in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of TARC and MDC among children with different manifestation of allergic diseases, such as bronchial asthma (BA), allergic rhinitis (AR) and atopic dermatitis (AD), and analyze relationship with blood eosinophil makers to find clinical significance of these markers.
Materials and Methods: A total of 49 children (14 BA, 13 AR and 13 AD) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (TARC, MDC) levels were analyzed. We examined whether serum levels of TARC and MDC would be related to serum IgE levels, blood eosinophils and serum eosinophil cationic protein (ECP) concentrations.
Results: Serum levels of TARC and MDC were significantly higher in children with BA and AD than those of controls. Serum levels of TARC and MDC were significantly related to serum IgE levels, blood eosinophil counts and serum ECP concentrations with different strength in children with allergic diseases.
Conclusion: Serum TARC and MDC may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum TARC and MDC might be involved in the pathophysiology of allergic diseases in children.
Materials and Methods: A total of 49 children (14 BA, 13 AR and 13 AD) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (TARC, MDC) levels were analyzed. We examined whether serum levels of TARC and MDC would be related to serum IgE levels, blood eosinophils and serum eosinophil cationic protein (ECP) concentrations.
Results: Serum levels of TARC and MDC were significantly higher in children with BA and AD than those of controls. Serum levels of TARC and MDC were significantly related to serum IgE levels, blood eosinophil counts and serum ECP concentrations with different strength in children with allergic diseases.
Conclusion: Serum TARC and MDC may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum TARC and MDC might be involved in the pathophysiology of allergic diseases in children.
목차
i. AbstractI. 서론II. 대상 및 방법III. 결과IV. 고찰V. 요약VI. 참고문헌
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