지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 20 - 36 (17page)
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초록· 키워드
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Importance: Ticks transmit severe human and animal diseases, posing global health and economic risks. Haemaphysalis longicornis spreads infections like Rickettsia, Theileria, and Anaplasma, exacerbating concerns. Conventional tick control, including chemical acaricides, faces challenges like toxicity, non-target effects, and resistance. Innovative, sustainable strategies are essential. Advances in tick antigen research have identified molecular targets, paving the way for anti-tick vaccines as a promising, eco-friendly alternative to manage H. longicornis infestations and reduce tick-borne disease transmission. This review explores recent discoveries in tick antigens, the development of recombinant proteins, and their knockdown effects on H. longicornis infestations.
Observations: Several novel antigens target essential physiological processes for tick survival. Reproductive and developmental antigens, such as subolesin and subolesin+cystatin, regulate immunity and reproduction, reducing blood feeding, oviposition, egg mass, and hatching rates. Knockdown of recombinant P27/30 impairs embryogenesis, significantly reducing larval survival. Chitinase inhibition disrupts molting, impairing nymph development. Metabolic enzymes like enolase and GSK-3β regulate homeostasis and energy production; their inhibition reduces feeding efficiency and survivability. Additionally, ribosomal protein S27 and troponin I-like protein, essential for protein synthesis and muscle contraction, respectively, impact tick growth and mobility.
These antigens may serve as valuable vaccine targets for controlling H. longicornis.
Conclusions and Relevance: Anti-tick vaccines offer a cost-effective, sustainable alternative to chemical controls. Advances in transcriptomics, genomics, and proteomics have identified promising antigens, with subolesin, chitinase, troponin I-like protein, GSK-3β, and enolase demonstrating strong potential. Enolase, affecting immunity, reproduction, and pathogen transmission, emerges as the most effective target for reducing H. longicornis infestations.
Observations: Several novel antigens target essential physiological processes for tick survival. Reproductive and developmental antigens, such as subolesin and subolesin+cystatin, regulate immunity and reproduction, reducing blood feeding, oviposition, egg mass, and hatching rates. Knockdown of recombinant P27/30 impairs embryogenesis, significantly reducing larval survival. Chitinase inhibition disrupts molting, impairing nymph development. Metabolic enzymes like enolase and GSK-3β regulate homeostasis and energy production; their inhibition reduces feeding efficiency and survivability. Additionally, ribosomal protein S27 and troponin I-like protein, essential for protein synthesis and muscle contraction, respectively, impact tick growth and mobility.
These antigens may serve as valuable vaccine targets for controlling H. longicornis.
Conclusions and Relevance: Anti-tick vaccines offer a cost-effective, sustainable alternative to chemical controls. Advances in transcriptomics, genomics, and proteomics have identified promising antigens, with subolesin, chitinase, troponin I-like protein, GSK-3β, and enolase demonstrating strong potential. Enolase, affecting immunity, reproduction, and pathogen transmission, emerges as the most effective target for reducing H. longicornis infestations.
목차
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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