지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 134 - 144 (11page)
이용수
초록· 키워드
오류제보하기
Background: Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.
Methods: The effects of total saponins from Panax Japonicus (TSPJs) in the intervention of aging-related obesity were explored. The in vitro and in vivo models were established using RAW264.7 macrophage cells and naturally aging rats and mice. The inflammation, iron content, and gene expressions of the models were analyzed. Senescence was induced in RAW264.7 cells with adriamycin (ADR), and Fth knockdown was introduced to the models to investigate related mechanisms.
Results: TSPJs reduced the iron content in the macrophages and prompted M2 polarization, which affected the JNK signaling pathway (p < 0.05) and reduced the expression of inflammatory cytokines in adipose tissue.
Conclusion: TSPJs mediate the iron metabolism of macrophages via Fth to reduce aging-related inflammation of the adipose tissue.
Methods: The effects of total saponins from Panax Japonicus (TSPJs) in the intervention of aging-related obesity were explored. The in vitro and in vivo models were established using RAW264.7 macrophage cells and naturally aging rats and mice. The inflammation, iron content, and gene expressions of the models were analyzed. Senescence was induced in RAW264.7 cells with adriamycin (ADR), and Fth knockdown was introduced to the models to investigate related mechanisms.
Results: TSPJs reduced the iron content in the macrophages and prompted M2 polarization, which affected the JNK signaling pathway (p < 0.05) and reduced the expression of inflammatory cytokines in adipose tissue.
Conclusion: TSPJs mediate the iron metabolism of macrophages via Fth to reduce aging-related inflammation of the adipose tissue.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
철 대사의 이해
Clinical Pediatric Hematology-Oncology
2018 .01
-
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles
대한암예방학회지
2021 .12
-
다회헌혈자의 철 결핍 예방을 위한 건강기능식품 철분제 복용의 효과
대한수혈학회지
2021 .08
-
The role of macrophages in gut inflammation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
The comparative effects of intravenous iron on oxidative stress and inflammation in patients with chronic kidney disease and iron deficiency: a randomized controlled pilot study
Kidney Research and Clinical Practice
2021 .01
-
Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation
Diabetes and Metabolism Journal
2023 .03
-
Differential Activation of Macrophages Based on Their Environment in Advanced Age
전남의대학술지
2020 .01
-
The regulatory function of Hes1 in metabolic disease related macrophage
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Application of ex-vivo generated macrophages as potential cell therapy
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Pro-Inflammatory Role of S1P<sub>3</sub> in Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Iron Reshapes the Gut Microbiome and Host Metabolism
지질·동맥경화학회지
2021 .01
-
Impact of Obesity-Related Inflammation on Cardiac Metabolism and Function
지질·동맥경화학회지
2021 .01
-
The Role of Vitamin D in Adipose Tissue Biology: Adipocyte Differentiation, Energy Metabolism, and Inflammation
지질·동맥경화학회지
2021 .01
-
SCAP deficiency in macrophages exacerbates inflammation by promoting M1 macrophage polarization
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Effectiveness of iron supplementation in the perioperative management of total knee arthroplasty: a systematic review
Knee Surgery and Related Research
2020 .01
-
Regulation of Macrophage Activation and Differentiation in Atherosclerosis
지질·동맥경화학회지
2021 .09
-
Melatonin significantly down-regulates long non-coding RNA Cox2 in M1 macrophages stimulated with LPS
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Comparison of the Efficacies of Parenteral Iron Sucrose and Oral Iron Sulfate for Anemic Patients with Inflammatory Bowel Disease in Korea
Gut and Liver
2016 .01
-
수혈성 철과잉증의 진단 및 치료
대한의사협회지
2022 .10
-
Cyclophilin A protects preterm birth by modulating macrophage polarization in a mouse model of inflammation-induced preterm birth
한국실험동물학회 학술발표대회 논문집
2021 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092457496