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논문 기본 정보

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학술저널
저자정보
Chia-Hung Wu (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan) Shih-Pin Chen (School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan Brain Research) Chih-Ping Chung (School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan) Kai-Wei Yu (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan) Te-Ming Lin (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan) Chao-Bao Luo (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Biomedical Engineering, Yu) Jiing-Feng Lirng (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan) I-Hui Lee (School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan) Feng-Chi Chang (Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan)
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중영문학회지 제26권 제3호
발행연도
2024.9
수록면
415 - 424 (10page)

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Background and Purpose This study aimed to investigate early changes in interstitial fluid (ISF) flow in patients with severe carotid stenosis after carotid angioplasty and stenting (CAS). Methods We prospectively recruited participants with carotid stenosis ≥80% undergoing CAS at our institute between October 2019 and March 2023. Magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), and the Mini-Mental State Examination (MMSE) were performed 3 days before CAS. MRI with DTI and MMSE were conducted within 24 hours and 2 months after CAS, respectively. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was calculated from the DTI data to determine the ISF status. Increments were defined as the ratio of the difference between post- and preprocedural values to preprocedural values. Results In total, 102 participants (age: 67.1±8.9 years; stenosis: 89.5%±5.7%) with longitudinal data were evaluated. The DTI-ALPS index increased after CAS (0.85±0.15; 0.85 [0.22] vs. 0.86±0.14; 0.86 [0.21]; P=0.022), as did the MMSE score (25.9±3.7; 24.0 [4.0] vs. 26.9±3.4; 26.0 [3.0]; P<0.001). Positive correlations between increments in the DTI-ALPS index and MMSE score were found in all patients (rs=0.468; P<0.001). Conclusion An increased 24-hour post-CAS DTI-ALPS index suggests early improvement in ISF flow efficiency. The positive correlation between the 24-hour DTI-ALPS index and 2-month MMSE score increments suggests that early ISF flow improvement may contribute to long-term cognitive improvement after CAS.

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