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논문 기본 정보

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저자정보
Harry Crane (Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia) Guy D. Eslick (NHMRC Centre for Research Excellence in Digestive Diseases, Hunter Medical Research Institute (HMRI), The University of Newcastle, Newcastle, NSW, Australia) Cameron Gofton (Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia; Department of Gastroenterology, Royal North Shore Hospital, S) Anjiya Shaikh (Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA) George Cholankeril (Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA) Mark Cheah (Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore) Jian-Hong Zhong (Hepatobiliary Surgery Department, Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Guangxi Medical University Cancer Hospital, Nanning, China) Gianluca Svegliati-Baroni (Liver Injury and Transplant Unit, Polytechnic University of Marche, Ancona, Italy) Alessandro Vitale (Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy) Beom Kyung Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea) Sang Hoon Ahn (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea) Mi Na Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea) Simone I Strasser (AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, VIC, Australia) Jacob George (Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.3
발행연도
2024.7
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436 - 448 (13page)

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Background/Aims: The global proportion of hepatocellular carcinoma (HCC) attributable to metabolic dysfunction- associated fatty liver disease (MAFLD) is unclear. The MAFLD diagnostic criteria allows objective diagnosis in the presence of steatosis plus defined markers of metabolic dysfunction, irrespective of concurrent liver disease. We aimed to determine the total global prevalence of MAFLD in HCC cohorts (total-MAFLD), including the proportion with MAFLD as their sole liver disease (single-MAFLD), and the proportion of those with concurrent liver disease where MAFLD was a contributary factor (mixed-MAFLD). Methods: This systematic review and meta-analysis included studies systematically ascertaining MAFLD in HCC cohorts, defined using international expert panel criteria including ethnicity-specific BMI cut-offs. A comparison of clinical and tumour characteristics was performed between single-MAFLD, mixed-MAFLD, and non-MAFLD HCC. Results: 22 studies (56,565 individuals with HCC) were included. Total and single-MAFLD HCC prevalence was 48.7% (95% confidence interval [CI] 34.5–63.0%) and 12.4% (95% CI 8.3–17.3%), respectively. In HCC due to chronic hepatitis B, C, and alcohol-related liver disease, mixed-MAFLD prevalence was 40.0% (95% CI 30.2– 50.3%), 54.1% (95% CI 40.4–67.6%) and 64.3% (95% CI 52.7–75.0%), respectively. Mixed-MAFLD HCC had significantly higher likelihood of cirrhosis and lower likelihood of metastatic spread compared to single-MAFLD HCC, and a higher platelet count and lower likelihood of macrovascular invasion compared to non-MAFLD HCC. Conclusions: MAFLD is common as a sole aetiology, but more so as a co-factor in mixed-aetiology HCC, supporting the use of positive diagnostic criteria.
#Fatty liver #Hepatocellular carcinoma #Epidemiology #Prevalence #Metabolic syndrome

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