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논문 기본 정보

자료유형
학술저널
저자정보
Lee Jun Yong (Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea) Kim Jie Hyun (Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea) Freedman Benjamin R. (Wyss Institute for Biologically Inspired Engineering, Harvard University) Mooney David J. (Wyss Institute for Biologically Inspired Engineering, Harvard University)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제21권 제6호
발행연도
2024.8
수록면
843 - 854 (12page)
DOI
10.1007/s13770-024-00651-3

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Background: Current dressing materials cannot secure a cell survival-promoting wound environment for stem cell delivery due to insufficient assimilation to skin motion. The authors developed a novel motion-accommodating dual-layer hydrogel dressing for stem cell delivery into such wounds. Methods: Dorsal hand skin movement was evaluated to determine the potential range of deformation for a dressing. The outer hydrogel (OH) was fabricated with an alginate–acrylamide double-network hydrogel with a covalently cross-linked elastomer coat. The tough adhesive consisted of a chitosan-based bridging polymer and coupling reagents. OH material properties and adhesiveness on porcine skin were measured. An oxidized alginate-based inner hydrogel (IH) containing human adipose-derived stem cells (ASCs) was evaluated for cell-supporting and cell-releasing properties. The OH’s function as a secondary dressing, and dual-layer hydrogel cell delivery potential in wounds were assessed in a rodent model. Results: The dual-layer hydrogel consisted of OH and IH. The OH target range of deformation was up to 25% strain. The OH adhered to porcine skin, and showed significantly higher adhesion energy than common secondary dressings and endured 900 flexion–extension cycles without detachment. OH showed a similar moisture vapor transmission rate as moisture-retentive dressings. IH maintained embedded cell survival for three days with significant cell release on the contacting surface. OH showed less fibrotic wound healing than other secondary dressings in vivo. The dual-layer hydrogel successfully delivered ASCs into open wounds of nude mice (13 ± 3 cells/HPF). Conclusions: The novel dual-layer hydrogel can accommodate patient movement and deliver ASCs into the wound bed by securing the wound microenvironment.

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