지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.1
- 수록면
- 27 - 32 (6page)
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초록· 키워드
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Importance: Hemochromatosis is rare in domestic animals, and iron-induced myopathy has not been reported in veterinary medicine. This case is the first report of iron-overload myopathy owing to hemochromatosis in a dog.
Case presentation: A 9-year-old spayed female Donggyeong dog presented with severe forelimb lameness. Necropsy revealed an enlarged liver and hemorrhagic lesions in the forelimb muscle. Microscopy showed iron components accumulation in multiple organs, including the liver, forelimb skeletal muscle, spleen, lymph node, and kidney. Prussian blue staining identified iron deposits in both macrophages and parenchymal cells, indicating that the iron accumulation was acquired rather than hereditary. Furthermore, iron components were observed within muscle fibers, accompanied by severe atrophy and myositis.
Conclusions and Relevance: Severe necrosis and mild fibrosis were observed in the liver and forelimb skeletal muscles. Based on histological analysis, we diagnosed iron overload myopathy by secondary hemochromatosis. Secondary hemochromatosis with severe muscle atrophy and myositis is very rare, and this is the first report of iron-overload myopathy in a dog.
Case presentation: A 9-year-old spayed female Donggyeong dog presented with severe forelimb lameness. Necropsy revealed an enlarged liver and hemorrhagic lesions in the forelimb muscle. Microscopy showed iron components accumulation in multiple organs, including the liver, forelimb skeletal muscle, spleen, lymph node, and kidney. Prussian blue staining identified iron deposits in both macrophages and parenchymal cells, indicating that the iron accumulation was acquired rather than hereditary. Furthermore, iron components were observed within muscle fibers, accompanied by severe atrophy and myositis.
Conclusions and Relevance: Severe necrosis and mild fibrosis were observed in the liver and forelimb skeletal muscles. Based on histological analysis, we diagnosed iron overload myopathy by secondary hemochromatosis. Secondary hemochromatosis with severe muscle atrophy and myositis is very rare, and this is the first report of iron-overload myopathy in a dog.
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ABSTRACT
INTRODUCTION
CASE PRESENTATION
DISCUSSION
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