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논문 기본 정보

자료유형
학술저널
저자정보
Ra Sang Hyun (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Chang Euijin (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kwon Ji-Soo (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Ji Yeun (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Son JuYeon (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Woori (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Jang Choi Young (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Jang Hyeon Mu (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Bae Seongman (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Jung Jiwon (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Min Jae (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Chong Yong Pil (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Lee Sang-Oh (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Choi Sang-Ho (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Yang Soo (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Lee Keun Hwa (Department of Microbiology, Hanyang University College of Medicine, Seoul, Korea.) Kim Sung-Han (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.35
발행연도
2024.9
수록면
1 - 10 (10page)
DOI
10.3346/jkms.2024.39.e237

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초록· 키워드

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Background: The pathophysiological mechanisms underlying the post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) are not well understood. Our study aimed to investigate various aspects of theses mechanisms, including viral persistence, immunological responses, and laboratory parameters in patients with and without PASC. Methods: We prospectively enrolled adults aged ≥ 18 years diagnosed with coronavirus disease 2019 (COVID-19) between August 2022 and July 2023. Blood samples were collected at three time-points: within one month of diagnosis (acute phase) and at 1 month, and 3 months post-diagnosis. Following a recent well-designed definition of PASC, PASC patients were defined as those with a questionnaire-based PASC score ≥ 12 persisting for at least 4 weeks after the initial COVID-19 diagnosis. Results: Of 57 eligible COVID-19 patients, 29 (51%) had PASC, and 28 (49%) did not. The PASC group had significantly higher nucleocapsid protein (NP) antigenemia 3 months after COVID-19 diagnosis (P = 0.022). Furthermore, several cytokines, including IL-2, IL-17A, VEGF, RANTES, sCD40L, IP-10, I-TAC, and granzyme A, were markedly elevated in the PASC group 1 and/or 3 month(s) after COVID-19 diagnosis. In contrast, the median values of several serological markers, including thyroid markers, autoimmune indicators, and stress-related hormones, were within the normal range. Conclusion: Levels of NP antigen and of various cytokines involved in immune responses become significantly elevated over time after COVID-19 diagnosis in PASC patients compared to non-PASC patients. This suggests that PASC is associated with prolonged immune dysregulation resulting from heightened antigenic stimulation.
#COVID-19 #Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) #Long-COVID #Nucleocapsid Protein (NP) #Cytokine

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