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논문 기본 정보

자료유형
학술저널
저자정보
Lee Young-Sun (Department of Biomedicine and Pharmaceutics, Dong-Eui University, Busan 47340, Republic of Korea) Lee Su-Jeong (Department of Biomedicine and Pharmaceutics, Dong-Eui University, Busan 47340, Republic of Korea) Jang Won Je (Department of Biomedicine and Pharmaceutics, Dong-Eui University, Busan 47340, Republic of KoreaResearch Institute for Microbiology, Dong-Eui University, Busan 47340, Republic of Korea) Lee Eun-Woo (Department of Biomedicine and Pharmaceutics, Dong-Eui University, Busan 47340, Republic of KoreaResearch Institute for Microbiology, Dong-Eui University, Busan 47340, Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.7
발행연도
2024.7
수록면
1,401 - 1,409 (9page)
DOI
10.4014/jmb.2403.03010

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초록· 키워드

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Postbiotics have various functional effects, such as antioxidant, anti-inflammatory, and anti-obesity. Levilactobacillus brevis BK3, the subject of this study, was derived from lactic acid bacteria isolated from Kimchi, a traditional Korean fermented food. The antioxidant activity of BK3 was confirmed through the measurements of 2,2-diphenyl-1-picryl-hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) (ABTS), and total antioxidant capacity (TAC). The wrinkle improvement effect was validated by assessing elastase inhibitory activity and collagenase inhibitory activity. The intracellular activity was confirmed using human keratinocytes (HaCaT) and human fibroblasts (HFF-1). BK3 protects skin cells from oxidative stress induced by H2O2 and reduces intracellular reactive oxygen species (ROS) production. In addition, the expressions of the antioxidant genes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were upregulated. Meanwhile, matrix metalloproteinase-1 (MMP-1) and collagen type I alpha 1 (COL1A1), involved in collagen degradation and synthesis, were significantly regulated. These results suggest the possibility of utilizing BK3 as a functional ingredient with antioxidant and wrinkle-improving effects.

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