지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 1,856 - 1,868 (13page)
- DOI
- 10.1038/s12276-024-01288-x
이용수
초록· 키워드
오류제보하기
Genomic alterations in tumors play a pivotal role in determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as a key clinical tool over the past decade, but advancements in sequencing costs and bioinformatics have now made whole-genome sequencing (WGS) a feasible single-assay approach for almost all cancer genomes in clinical settings. This paper reports on the findings of a prospective, single-center study exploring the real-world clinical utility of WGS (tumor and matched normal tissues) and has two primary objectives: (1) assessing actionability for therapeutic options and (2) providing clarity for clinical questions. Of the 120 patients with various solid cancers who were enrolled, 95 (79%) successfully received genomic reports within a median of 11 working days from sampling to reporting. Analysis of these 95 WGS reports revealed that 72% (68/95) yielded clinically relevant insights, with 69% (55/79) pertaining to therapeutic actionability and 81% (13/16) pertaining to clinical clarity. These benefits include the selection of informed therapeutics and/or active clinical trials based on the identification of driver mutations, tumor mutational burden (TMB) and mutational signatures, pathogenic germline variants that warrant genetic counseling, and information helpful for inferring cancer origin. Our findings highlight the potential of WGS as a comprehensive tool in precision oncology and suggests that it should be integrated into routine clinical practice to provide a complete image of the genomic landscape to enable tailored cancer management.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The shaping of cancer genomes with the regional impact of mutation processes
Experimental and Molecular Medicine
2022 .07
-
Paired analysis of tumor mutation burden calculated by targeted deep sequencing panel and whole exome sequencing in non-small cell lung cancer
BMB Reports
2021 .01
-
IEC TC82 WG3 WG6 동향보고서
한국태양광발전학회지
2018 .08
-
Comparative oncology: overcoming human cancer through companion animal studies
Experimental and Molecular Medicine
2023 .04
-
Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants
Experimental and Molecular Medicine
2024 .04
-
Mutational spectrum of SARS-CoV-2 during the global pandemic
Experimental and Molecular Medicine
2021 .08
-
Genomic characterization of clonal evolution during oropharyngeal carcinogenesis driven by human papillomavirus 16
BMB Reports
2018 .01
-
Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
Experimental and Molecular Medicine
2024 .07
-
Standardization Issues in JTC 1/SC 29/WG 7
한국방송미디어공학회 학술발표대회 논문집
2024 .06
-
MgO 기반 용융염 담지 CO₂흡착제를 이용한 상용 WGS 촉매 기반
한국에너지기후변화학회 학술대회
2024 .11
-
희토류 관련 국제표준 동향 및 시사점
한국분말야금학회지
2018 .01
-
광역 온도 범위 WGS 및 CO₂ 분리 시스템
한국에너지기후변화학회 학술대회
2022 .10
-
WG 4 - MPEG Video 표준화 현황
한국방송미디어공학회 학술발표대회 논문집
2024 .06
-
임상시험을 위한 연구계획서의 오류에 대한 고찰
보건정보통계학회지
2021 .01
-
Classification of histological types of primary lung cancer from CT images using clinical information
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
ISO/TC276 WG5 : Data Processing and Integration
한국생물공학회 학술대회
2016 .10
-
Birth of an ‘Asian cool’ reference genome: AK1
BMB Reports
2016 .01
최근 본 자료
댓글(0)
0