Purpose: This study aimed to identify the health-related quality of life (HRQoL) of adults who experience dizziness and imbalance and those who do not, as measured using the health-related quality of life instrument with eight items(HINT-8), and determine the factors related to HRQoL. Methods: This study is a secondary data analysis of data obtained from the 2021 Korea National Health and Nutrition Examination Survey. Participants were 3,959 adults, aged 40 years or older. Data were analyzed using SPSS/WIN 27.0. Descriptive statistics, chi-squared test, t-test, and general linear regression analysis were performed. Results: The group that experienced dizziness and imbalance had significantly lower HRQoL scores for stair climbing, pain, energy, work, depression, memory, sleep, and happiness than the group without dizziness or imbalance. Factors related to HRQoL in the dizziness and imbalance group included age, educational level, activity limitation, stress, anxiety, subjective health status, and subjective tinnitus. Conclusion: To improve the HRQoL of individuals wih dizziness and imbalance, programs that integrate psychological interventions for stress, anxiety, and subjective health status, with physical interventions are necessary.