Purpose: This study aimed to explore how digital health literacy and health empowerment influence health promotion behaviors in middle-aged women. Methods: We conducted a cross-sectional descriptive study via online questionnaires among 197 middle-aged women. Data were collected from April 24, 2024, to May 24, 2024, using the Health Promoting Lifestyle Profile II, Digital Health Literacy Instrument, and Korean Health Empowerment Scale. Results: Health empowerment, interest in health, and perceived health status significantly influenced health promotion behaviors among middleaged women, with a total explanatory power of 38%. Conclusion: To improve health promotion behaviors in middle-aged women, strategies to enhance health empowerment are essential. Consequently, we recommend developing diverse educational interventions to boost both interest in health and perceived health status among this demographic.