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논문 기본 정보

자료유형
학술저널
저자정보
배효은 (Department of Neurology, Kangdong Sacred Heart Hosptial, Hallym University College of Medicine) 박인성 (International Institute for Integrative Sleep Medicine (IIIS), University of Tsukuba, Tsukuba, Japan) 주은연 (Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한수면연구학회 Journal of sleep medicine Journal of sleep medicine 제21권 제1호
발행연도
2024.4
수록면
44 - 50 (7page)
DOI
10.13078/jsm.240006

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Objectives: Insomnia is a common sleep disorder, and various strategies have been explored for its treatment. One of the methods involves the administration of carbon dioxide (CO<sub>2</sub>) at bedtime, as the CO<sub>2</sub> increment exerts a sedative effect on the central nervous system. We aimed to assess the effect of CO<sub>2</sub> on sleep quality in patients with insomnia using the coefficient of variation of the envelope (CVE) analysis, a novel analytical method. Methods: In this randomized, double-blind, sham-controlled crossover trial, 24 adults with sleeping difficulties underwent level 1 polysomnography. Two interventions involved exposure to either 2% low-concentration CO<sub>2</sub> gas or room air. CVE analysis was performed to assess the stability of the delta band. Morphological variations in delta waves can be quantitatively monitored using the envelope analysis, which assesses the effect of manipulations on sleep that may otherwise elude detection. Results: Exposure to CO<sub>2</sub> improved the total sleep time (TST) (<i>p</i>=0.010) and total arousal index (TAI) (<i>p</i>=0.011). The CVE analysis showed a distinct distribution between the experimental and sham-controlled groups. Moreover, correlations between the TST and CVE (r=0.41) and those between the TAI and CVE (r=0.40) were observed. Conclusions: This study is the first to evaluate the effects of CO<sub>2</sub> exposure on sleep stability in patients with insomnia. The CVE analysis implies the possibility of sleep stabilization by CO<sub>2</sub> administration and suggests a link between enhanced sleep maintenance and sleep stability.

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