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논문 기본 정보

자료유형
학술저널
저자정보
Johanna Vaylen M. Sarmiento (St. Luke’s Medical Center, Institute for Neurosciences, Quezon City, Philippines) Rhoderick M. Casis (St. Luke’s Medical Center, Institute for Neurosciences, Quezon City, Philippines) Paul Vincent A. Opinaldo (St. Luke’s Medical Center, Institute for Neurosciences, Quezon City, Philippines)
저널정보
대한뇌종양학회 Brain Tumor Research and Treatment Brain Tumor Research and Treatment Vol.12 No.2
발행연도
2024.4
수록면
121 - 124 (4page)

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We discuss a patient with a tumor on the anterior corpus callosum who underwent open biopsy even- tually succumbing to cerebrogenic fatal arrhythmia following wounded glioma syndrome. A healthy 37-year-old female patient was admitted to our department due to a history of headache for 13 months. MRI revealed a suspicious glioma infiltrating the anterior corpus callosum. Neurologic examination only showed low cognitive assessment score (Montreal Cognitive Assessment score 20/30). ECG was nor- mal sinus rhythm. Steroids and levetiracetam were administered prior to operation. Patient underwent right frontal craniotomy and biopsy of tumor with unremarkable events. During the first hospital day, patient had episodes of bradycardia followed by decrease in sensorium. Brain CT scan showed pro- gression of edema without hemorrhage within the tumor bed. This was followed minutes later by two episodes of generalized tonic-clonic seizures and pulseless ventricular tachycardia. Cardiac resuscita- tion was done for 24 minutes but patient eventually expired. Location of the lesion and the epileptoge- nicity of the peritumoral cortex greatly contributed to the patient’s demise. Involvement of the fronto- mesial structures, particularly the insula and the cingulate cortex, and their connection to the central autonomic network, increased susceptibility to arrhythmias. Decreased seizure threshold worsened post-operative edema, further aggravating the dysregulation of the brain-heart-connection.

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