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논문 기본 정보

자료유형
학술저널
저자정보
Jihyun Cha (Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea) Ji Hwan Yun (Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea) Ji Hye Choi (Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea) Jae Ho Lee (Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of KoreaGraduate Training Program of Korean Medical Therapeutics for Healthy Agi) Byung Tae Choi (Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of KoreaDepartment of Korean Medical Science, School of Korean Medicine, Pusan National) Hwa Kyoung Shin (Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of KoreaDepartment of Korean Medical Science, School of Korean Medicine, Pusan National)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture Vol.27 No.2
발행연도
2024.6
수록면
70 - 81 (12page)
DOI
10.3831/KPI.2024.27.2.70

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Objectives: Cognitive impairments, ranging from mild to severe, adversely affect daily functioning, quality of life, and work capacity. Despite significant efforts in the past decade, more than 200 promising drug candidates have failed in clinical trials. Herbal remedies are gaining interest as potential treatments for dementia due to their long history and safety, making them valuable for drug development. This review aimed to examine the mechanisms behind the effect of Polygonum multiflorum on cognitive function. Methods: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer’s disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum’s impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum’s effects on cognitive decline and AD. Results: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis. Conclusion: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.

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