지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.4
- 수록면
- 567 - 579 (13page)
- DOI
- 10.4143/crt.2023.897
이용수
초록· 키워드
오류제보하기
Purpose Programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors have shown efficacy in metastatic esophageal squamous cell carcinoma (ESCC) therapy. However, data is still limited regarding neoadjuvant immunotherapy for operable ESCC.
Materials and Methods Patients with clinical stage T2 or T3 and N0 ESCC received three cycles of nivolumab therapy every two weeks before surgical resection. The primary endpoint is major pathologic responses (MPR) rate (≤ 10% of residual viable tumor [RVT]).
Results Total 20 patients completed the planned nivolumab therapy. Among them, 17 patients underwent surgery as protocol, showing MPR in two patients (MPR rate, 11.8%), including one pathologic complete response, on conventional pathologic response evaluation. Pathologic response was re-evaluated using the immune-related pathologic response criteria based on immune-related RVT (irRVT). Three patients were classified as immunologic major pathologic response (iMPR; ≤ 10% irRVT, iMPR rate: 17.6%), five as pathologic partial response (> 10% and < 90% irRVT), and nine as pathologic nonresponse (≥ 90% irRVT). The combined positive score (CPS) for PD-L1 in the baseline samples was predictable for iMPR, with the probability as 37.5% in CPS ≥ 10 (3/8) and 0% in CPS < 10 (0/9).
Conclusion Although the efficacy of neoadjuvant nivolumab therapy was modest in unselected ESCC patients, further researches on neoadjuvant immunotherapy are necessary in patients with PD-L1 expressed ESCC.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Neoadjuvant Nivolumab plus Gemcitabine/Cisplatin Chemotherapy in Muscle-Invasive Urothelial Carcinoma of the Bladder
Cancer Research and Treatment
2023 .04
-
Predictive Factor of the Pathologic Complete Response after the Neoadjuvant Treatment of the HER2 Positive Breast Cancer
대한외과학회 학술대회 초록집
2022 .05
-
Four-Tier Pathologic Tumor Regression Grading System Predicts the Clinical Outcome in Patients Who Undergo Surgical Resection for Locally Advanced Pancreatic Cancer after Neoadjuvant Chemotherapy
Gut and Liver
2022 .01
-
p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Regulatory Network of MicroRNAs, Host Genes, Target Genes and Transcription Factors in Human Esophageal Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Radiologic complete response after neoadjuvant chemotherapy in advanced breast cancer can predict survival outcome, but not pathologic complete response
대한외과학회 학술대회 초록집
2019 .10
-
Prevalence of Pathologic Nodal Disease among Breast Cancer Patients undergoing Novel Neoadjuvant Chemotherapy
대한외과학회 학술대회 초록집
2023 .05
-
What Should We Do, If We Cannot Find The Tumor after Neoadjuvant Therapy?
대한외과학회 학술대회 초록집
2019 .10
-
식도암의 수술적 치료
대한의사협회지
2024 .02
-
Esophageal squamous cell carcinoma in a Dachshund with congenital type 9 vascular ring anomaly: a case report
Korean Journal of Veterinary Research(대한수의학회지)
2025 .03
-
Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
[Breast] Risk Factors of Breast Cancer Recurrence in Pathologic Complete Response (pCR) Achieved Post Neoadjuvant Chemotherapy (NAC) Patients
대한외과학회 학술대회 초록집
2022 .11
-
Oncologic Outcome between Pathologic T4 and Pathologic T3 Patients Diagnosed with Clinical T4 Colon Cancer on Preoperative Computed Tomography Scan
대한외과학회 학술대회 초록집
2022 .11
-
Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms
Gut and Liver
2016 .01
-
Prediction of Axillary Lymph Node Response Based on Breast Pathologic Complete Response and Breast Cancer Subtype after Neoadjuvant Chemotherapy
대한임상종양학회 학술대회지
2019 .02
-
Current Status of Pathologic Examinations in Korea, 2011–2015, Based on the Health Insurance Review and Assessment Service Dataset
Journal of Pathology and Translational Medicine
2017 .01
-
Clinical characteristics of rectal cancer patients with neoadjuvant chemoradiotherapy: a nationwide population-based cohort study in South Korea
Annals of Surgical Treatment and Research
2021 .05
-
Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2
Cancer Research and Treatment
2017 .01
-
Endoscopic Submucosal Dissection for Recurrent or Residual Superficial Esophageal Cancer after Chemoradiotherapy: Two Cases
Clinical Endoscopy
2015 .01
-
Overexpression of miR-191 Predicts Poor Prognosis and Promotes Proliferation and Invasion in Esophageal Squamous Cell Carcinoma
Yonsei Medical Journal
2017 .01
최근 본 자료
댓글(0)
0