지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 17 - 29 (13page)
이용수
초록· 키워드
오류제보하기
Importance: Ovine pulmonary adenomatosis (OPA) and maedi-visna disease (MVD) are chronic and progressive infectious diseases in sheep caused by Jaagsiekte sheep retrovirus (JSRV) and maedi-visna virus (MVV), respectively.
Objective: To investigate the pathological changes and conduct viral gene analysis of OPA and MVD co-occurrence in Inner Mongolia, China.
Methods: Using gross pathology, histopathology, immunohistochemistry, ultrastructural pathology, PCR, and sequence analysis, we investigated the concurrent infection of JSRV and MVV in 319 Dorper rams slaughtered in a private slaughterhouse in Inner Mongolia, in 2022.
Results: Of the 319 rams included, 3 showed concurrent JSRV and MVV infection. Gross lung pathology showed diffuse enlargement, consolidation, and greyish-white miliary nodules on the lung surface; the trachea was filled with a white foamy fluid; hilar and mediastinal lymph nodes were significantly enlarged. Histopathology results revealed typical OPA and MVD lesions in the lung tissue. Immunohistochemical results were positive for JSRV envelope protein (Env) in the tumor cells and MVV CA in alveolar macrophages. Transmission electron microscopy showed several virions and autophagosomes in the lung tissue, severely damaged mitochondria, and the induced mitophagy. Nucleotide sequences obtained for JSRV env and MVV gag showed the highest homology with the Inner Mongolian strains of JSRV env (JQ837489) and MVV gag (MW248464).
Conclusions and Relevance: Our study confirmed that OPA and MVD co-occurrence and identified the pathological changes in Inner Mongolia, China, thereby providing references for the identification of concurrent JSRV and MVV infections.
Objective: To investigate the pathological changes and conduct viral gene analysis of OPA and MVD co-occurrence in Inner Mongolia, China.
Methods: Using gross pathology, histopathology, immunohistochemistry, ultrastructural pathology, PCR, and sequence analysis, we investigated the concurrent infection of JSRV and MVV in 319 Dorper rams slaughtered in a private slaughterhouse in Inner Mongolia, in 2022.
Results: Of the 319 rams included, 3 showed concurrent JSRV and MVV infection. Gross lung pathology showed diffuse enlargement, consolidation, and greyish-white miliary nodules on the lung surface; the trachea was filled with a white foamy fluid; hilar and mediastinal lymph nodes were significantly enlarged. Histopathology results revealed typical OPA and MVD lesions in the lung tissue. Immunohistochemical results were positive for JSRV envelope protein (Env) in the tumor cells and MVV CA in alveolar macrophages. Transmission electron microscopy showed several virions and autophagosomes in the lung tissue, severely damaged mitochondria, and the induced mitophagy. Nucleotide sequences obtained for JSRV env and MVV gag showed the highest homology with the Inner Mongolian strains of JSRV env (JQ837489) and MVV gag (MW248464).
Conclusions and Relevance: Our study confirmed that OPA and MVD co-occurrence and identified the pathological changes in Inner Mongolia, China, thereby providing references for the identification of concurrent JSRV and MVV infections.
목차
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Next-generation sequencing for the genetic characterization of Maedi/Visna virus isolated from the northwest of China
Journal of Veterinary Science
2021 .11
-
Adverse Prognostic Impact of Bone Marrow Microvessel Density in Multiple Myeloma
Annals of Laboratory Medicine
2015 .01
-
Effects of high occupational physical activity, aging, and exercise on heart rate variability among male workers
대한직업환경의학회지
2015 .09
-
Genetic analysis of env and gag gene fragments of bovine leukemia virus identified in cattle from Korea
Korean Journal of Veterinary Research(대한수의학회지)
2015 .03
-
Evaluation of different media for ex vivo porcine lung culture model
한국가축위생학회지
2018 .01
-
Intermittent Oroesophageal Tube Feeding via the Airway in Patients With Dysphagia
Annals of Rehabilitation Medicine
2016 .01
-
Infection
대한외과학회 학술대회 초록집
2019 .10
-
Microvessel Density as a Prognostic Factor in Ovarian Cancer: a Systematic Review and Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Interstitial Lung Disease and Lung Cancer Development: A 5-Year Nationwide Population-Based Study
Cancer Research and Treatment
2018 .01
-
Development of an Automated Image Analyzer for Microvessel Density Measurement in Bone Marrow Biopsies
Annals of Laboratory Medicine
2020 .01
-
Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Clinico-pathological Analysis of the Lungs from Patients with Lung Transplantation in a Single Institute in Korea
Journal of Korean Medical Science
2015 .01
-
무작위 속도 변화에 의한 트레드밀 보행훈련이 뇌졸중 환자의 폐기능에 미치는 영향
대한물리의학회지
2016 .01
-
The Expression and Relationship of CD68-Tumor-Associated Macrophages and Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell Carcinoma
Clinical and Experimental Otorhinolaryngology
2016 .01
-
Correlation between Microvascular Density and Matrix Metalloproteinase 11 Expression in Prostate Cancer Tissues: a Preliminary Study in Thailand
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Chronic Hepatitis C Virus Infection, Why Not Treat Now?
대한류마티스학회지
2018 .01
-
Risk for infection
대한외과학회 학술대회 초록집
2015 .11
-
Persistent Effort to Control Infection after Lung Transplantation in Korea
Infection and Chemotherapy
2020 .01
-
NADPH Oxidase 4-mediated Alveolar Macrophage Recruitment to Lung Attenuates Neutrophilic Inflammation in Staphylococcus aureus Infection
Immune Network
2023 .10
-
정상 성인 호흡기능에 대한 들숨 근 강화훈련과 날숨 근 강화 훈련의 효과 비교
대한통합의학회지
2016 .03
최근 본 자료
댓글(0)
0