지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.10
- 수록면
- 663 - 673 (11page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Poly-γ-glutamic acid (γ-PGA), a natural polymer found in fermented soybean products, has been reported to play a prebiotic role in the gut. This intervention study investigated the effects of γ-PGA-containing supplement consumption on urinary microbiota in healthy adults because of limited data on such investigation.
SUBJECTS/METHODS: A 4-week parallel trial including 39 male and female Korean adults, who were free of chronic diseases and infection, was designed as a randomized, doubleblinded, placebo-controlled study. A total of 30 participants completed the study wherein the intervention group (n = 17) received a mixture supplement containing 600 mg/day of γ-PGA and 100 mg/day of vitamin B6, while the control group (n = 13) received a placebo. Paired datasets (baseline and endpoint data) of microbiota profiles, which were constructed via urinary assays of microbe-derived extracellular vesicles, were analyzed and compared between the two groups.
RESULTS: Only the intervention group yielded significant results for the Bray-Curtis and Jaccard dissimilarity indices between baseline and endpoint data (P < 0.05). In the phylumlevel analysis of microbial composition, the Firmicutes to Bacteroidetes ratio (FB ratio) tended to decrease from baseline in the intervention group; however, it increased in the control group. Differences between the baseline and endpoint FB ratios were significant between the two groups (P < 0.05).
CONCLUSION: This study’s findings suggest that γ-PGA-vitamin B6 supplementation potentially alters the microbial community composition of a host. Further investigation into the biological consequences of commensal microbiota alteration by γ-PGA-containing supplement consumption is warranted.
SUBJECTS/METHODS: A 4-week parallel trial including 39 male and female Korean adults, who were free of chronic diseases and infection, was designed as a randomized, doubleblinded, placebo-controlled study. A total of 30 participants completed the study wherein the intervention group (n = 17) received a mixture supplement containing 600 mg/day of γ-PGA and 100 mg/day of vitamin B6, while the control group (n = 13) received a placebo. Paired datasets (baseline and endpoint data) of microbiota profiles, which were constructed via urinary assays of microbe-derived extracellular vesicles, were analyzed and compared between the two groups.
RESULTS: Only the intervention group yielded significant results for the Bray-Curtis and Jaccard dissimilarity indices between baseline and endpoint data (P < 0.05). In the phylumlevel analysis of microbial composition, the Firmicutes to Bacteroidetes ratio (FB ratio) tended to decrease from baseline in the intervention group; however, it increased in the control group. Differences between the baseline and endpoint FB ratios were significant between the two groups (P < 0.05).
CONCLUSION: This study’s findings suggest that γ-PGA-vitamin B6 supplementation potentially alters the microbial community composition of a host. Further investigation into the biological consequences of commensal microbiota alteration by γ-PGA-containing supplement consumption is warranted.
목차
ABSTRACT
INTRODUCTION
SUBJECTS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Consumption of poly-γ-glutamatevitamin B6 supplement and urinary microbiota profiles in Korean healthy adults: a randomized, double-blinded, placebo-controlled intervention study
Nutrition Research and Practice
2024 .10
-
Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut
Journal of Microbiology and Biotechnology
2017 .01
-
Roads to Construct and Re-build Plant Microbiota Community
The Plant Pathology Journal
2022 .10
-
Optimized Production of Poly(γ-Glutamic acid) By Bacillus sp. FBL-2 through Response Surface Methodology Using Central Composite Design
Journal of Microbiology and Biotechnology
2019 .01
-
An Efficient Method for the Release of Recombinant Penicillin G Amidase from the Escherichia coli Periplasm
생명과학회지
2017 .10
-
Immobilization and Performance of Penicillin G Acylase on Magnetic Ni0.7Co0.3Fe2O4@SiO2-CHO Nanocomposites
Journal of Microbiology and Biotechnology
2019 .01
-
Individualized Responses of Gut Microbiota to Dietary Intervention
한국미생물학회 학술대회논문집
2018 .04
-
Probiotic supplementation has sex-dependent effects on immune responses in association with the gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial
Nutrition Research and Practice
2023 .10
-
Probiotic supplementation has sex-dependent effects on immune responses in association with the gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial
Nutrition Research and Practice
2023 .10
-
Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing
Journal of Microbiology and Biotechnology
2015 .01
-
The Role of the Microbiota in Asthma
한국미생물학회 학술대회논문집
2015 .04
-
Is the Human Gut Microbiota Controlled by Genetic Factors? Or, Is It Controlled by Acquired Factors?
한국미생물학회 학술대회논문집
2018 .04
-
Gut Microbiota, Probiotics, and Health
한국미생물학회 학술대회논문집
2019 .04
-
In Vivo Hair Growth Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid from Bacillus subtilis (Chungkookjang)
Journal of Microbiology and Biotechnology
2015 .01
-
The inhibitory effect of gut microbiota and its metabolites on colorectal cancer
Journal of Microbiology and Biotechnology
2020 .01
-
Changes of Gut Microbiota in Carbapenem-resistant Enterobacteriaceae Patients after Fecal Microbiota Transplantation
한국미생물학회 학술대회논문집
2020 .10
-
진앙위치 부근 관측소에 도달한 S파 PGA 값을 활용한 지진조기경보시스템 발령기준 결정조건 연구
대한지질학회 학술대회
2018 .10
-
Microbiota-induced Vitamin A Transport and Its Role in the Intestinal Immunity
한국미생물학회 학술대회논문집
2022 .10
-
Personalized Diets based on the Gut Microbiome as a Target for Health Maintenance: from Current Evidence to Future Possibilities
Journal of Microbiology and Biotechnology
2022 .12
-
Comparison of Gut Microbiota between Lean and Obese Adult Thai Individuals
한국미생물·생명공학회지
2018 .01
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-090888233