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논문 기본 정보

자료유형
학술저널
저자정보
Lee Hye Mi (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea) Hyeon Hee Lee (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea) Young Cheon Na (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea) Choi Keum Ha (Department of Pathology, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea)
저널정보
대한창상학회 Journal of Wound Management and Research Journal of Wound Management and Research Vol.20 No.1
발행연도
2024.2
수록면
36 - 45 (10page)
DOI
10.22467/jwmr.2023.02845

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Background: Keloid and hypertrophic scars are prominent scars that are excessively repaired with upregulated synthesis, deposition, and accumulation of collagen. Topical agents are used to reduce inflammation and fibrotic changes via reduced transepithelial water loss. Increased mechanical pressure applied through scar massage can accelerate scar maturation by inducing fibroblast proliferation, which enhances the remodeling of connective tissue matrices and collagen degradation.Methods: This study comparatively analyzed the effectiveness of topical agents applied to post-burn wounds on the dorsal surface of Sprague-Dawley rats through twice-daily massaging. Postoperative histological analysis of the tissues was performed after surgical en bloc removal of the treatment area at 4, 10, and 16 weeks.Results: Histological analyses revealed larger amounts of fibroblasts in Mepiform and Scarnos gel-treated tissue than in Vaseline-treated tissue. Granulation was prevented in scars treated with the topical agents.Conclusion: Mepiform Ultra scar gel and Scarnos gel, accompanied by massaging, may be effective anti-scarring topical agents to alleviate contact burn scars in Sprague-Dawley rats.

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