메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
김태균 (대구가톨릭대학교 의과대학 이비인후과학교실) 황보창호 (대구가톨릭대학교 의과대학 이비인후과학교실) 이승환 (대구가톨릭대학교) 예미경 (대구가톨릭대학교) 신승헌 (대구가톨릭대학교)
저널정보
대한이비인후과학회 부산,울산,경남 지부회 임상이비인후과 임상이비인후과 제35권 제1호
발행연도
2024.3
수록면
3 - 11 (9page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background and Objectives: Aspergillus fumigatus is commonly associated with airway inflammatory diseases. Zinc oxide (ZO) is known to be an essential microelement that facilitates fungal survival, growth, and proliferation. This study aimed to investigate the impact of ZO on A. fumigatus-induced fungal sinusitis in rabbit. Materials and Methods: Sixteen New Zealand white rabbits divided into five groups for this study. Group 1 (5 sides) served as the negative control, Group 2 (6 sides) received phosphate buffer saline (PBS) without ZO, Group 3 (7 sides) received PBS with ZO, Group 4 (7 sides) was exposed to A. fumigatus without ZO, and Group 5 (7 sides) was exposed to A. fumigatus with ZO. After 28 days, histological and mycologic examinations, cytokine analysis, and transcription factor evaluation were conducted. Results: The intramaxillary instillation of A. fumigatus conidia led to increase protein and mRNA expression of interleukin (IL)-1β and IL-8 in the maxillary sinus mucosa. These changed in chemical mediator production were associated with the activation of nuclear factor-κB and p38. Furthermore, intramaxillary instillation of fungal conidia resulted in significant enhancement of inflammatory cell infiltration and epithelial thickening. Notably, fungal biofilm formation was significantly increased in group 4 and 5. However, sub-mucoperiosteal application of ZO did not have a significant impact on A. fumigatus-induced inflammation of maxillary sinus mucosa. Conclusion: While intramaxillary instillation of A. fumigatus increased mucosal inflammation, cytokine production, and biofilm formation, the sub- mucoperiosteal application of ZO did not have a significant influence on inflammation in the maxillary sinus mucosa.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

최근 본 자료

전체보기

댓글(0)

0