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논문 기본 정보

자료유형
학술저널
저자정보
Gabriel Faria-Costa (Department of Urology, Unidade Local de Saúde de Matosinhos) João Oliveira (Department of Urology, University Hospital Center São João) Inês Vilas-Boas (Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto) Inês Campelo (Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto) Elisa Azeredo Silva (Unit of Experimental Biology, Department of Biomedicine, Faculty of Medicine, University of Porto) Carmen Brás-Silva (UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto) Susana Maria Silva (Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto) Tiago Antunes-Lopes (Department of Urology, University Hospital Center São João) Ana Charrua (Unit of Experimental Biology, Department of Biomedicine, Faculty of Medicine, University of Porto)
저널정보
대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal Vol.28
발행연도
2024.2
수록면
2 - 11 (10page)
DOI
10.5213/inj.2346250.125

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Metabolic syndrome (MS) is associated with both cardiovascular and bladder dysfunction. Insulin resistance (IR) and central obesity, in particular, are the main risk factors. In these patients, vicious pathological cycles exacerbate abnormal carbohydrate metabolism and sustain an inflammatory state, with serious implications for both the heart and bladder. Ketone bodies serve as an alternative energy source in this context. They are considered a “super-fuel” because they generate adenosine triphosphate with less oxygen consumption per molecule, thus enhancing metabolic efficiency. Ketone bodies have a positive impact on all components of MS. They aid in weight loss and glycemic control, lower blood pressure, improve lipid profiles, and enhance endothelial function. Additionally, they possess direct anti-inflammatory, antioxidant, and vasodilatory properties. A shared key player in dysfunction of both the heart and bladder dysfunction is the formation of the NLRP3 inflammasome, which ketone bodies inhibit. Interventions that elevate ketone body levels—such as fasting, a ketogenic diet, ketone supplements, and sodium-glucose cotransporter 2 inhibitors—have been shown to directly affect cardiovascular outcomes and improve lower urinary tract symptoms derived from MS. This review explores the pathophysiological basis of the benefits of ketone bodies in cardiac and bladder dysfunction.

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