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논문 기본 정보

자료유형
학술저널
저자정보
Kim Byung-Wook (Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea) Park Jong-Jae (Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea) Moon Hee Seok (Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.) Lee Wan Sik (Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea) Shim Ki-Nam (Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea) Baik Gwang Ho (Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea) Lim Yun Jeong (Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea) Lee Hang Lak (Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea) Youn Young Hoon (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea) Park Jun Chul (Department of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea) Sung In-Kyung (Department of Internal Medicine, Konkuk University Medical Center, Konkuk University College of Medicine, Seoul, Korea) Chung Hyunsoo (Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.) Moon Jeong Seop (Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea) Kim Gwang Ha (Department of Internal Medicine, Pusan National University College of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea) Hong Su Jin (Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea) Choi Hyuk Soon (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.2
발행연도
2024.3
수록면
257 - 264 (8page)
DOI
10.5009/gnl230242

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Background/Aims: Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers. Methods: Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours. The patients were randomly allocated to either the tegoprazan or esomeprazole group. Tegoprazan 50 mg or esomeprazole 40 mg were administered for 4 weeks, after which gastroscopic evaluation was performed. If the artificial ulcer had not healed, the same dose of tegoprazan or esomeprazole was administered for an additional 4 weeks, and a gastroscopic evaluation was performed. Results: One hundred sixty patients were enrolled in this study. The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in the tegoprazan and esomeprazole groups, respectively (p=0.006). At 8 weeks after ESD, the cumulative ulcer healing rates were 73.7% (56/76) and 77.9% (53/68) in the tegoprazan and esomeprazole groups, respectively (p=0.210). Delayed bleeding occurred in two patients in the tegoprazan group (2.6%) and in one patient in the esomeprazole group (1.5%). Other adverse events were negligible in both groups. Conclusions: Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.
#Tegoprazan #Endoscopic resection #Endoscopic submucosal dissection #Gastric neoplasia #Multicenter prospective randomized study

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