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논문 기본 정보

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학술저널
저자정보
Shintaro Akiyama (Department of Gastroenterology, nstitute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Tsubasa Onoda (Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Moue Shoko (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.) Noriaki Sakamoto (Department of Pathology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Taku Sakamoto (Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Hideo Suzuki (Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Enomoto Tsuyoshi (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.) Daisuke Matsubara (Department of Pathology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) Oda Tatsuya (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.) Kiichiro Tsuchiya (Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.22 No.1
발행연도
2024.1
수록면
92 - 103 (12page)
DOI
10.5217/ir.2023.00105

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Background/Aims: Mucosal adaptation of the ileum toward colonic epithelium has been reported in pouchitis in ulcerative colitis (UC); however, the clinical characteristics, endoscopic findings, and outcomes in patients with pouchitis with ileal mucosal adaptation are poorly understood.Methods: This was a single-center retrospective study comprising UC patients treated by proctocolectomy with ileal pouch-anal anastomosis who had undergone pouchoscopy at the University of Tsukuba Hospital between 2005 and 2022. Endoscopic phenotypes were evaluated according to the Chicago classification. High-iron diamine staining (HID) was performed to identify sulfomucin (colon-type mucin)-producing goblet cells (GCs) in pouch biopsies. We compared clinical data between patients with (high HID group) and without > 10% sulfomucin-producing GCs in at least one biopsy (low HID group).Results: We reviewed 390 endoscopic examination reports from 50 patients. Focal inflammation was the most common phenotype (78%). Five patients (10%) required diverting ileostomy. Diffuse inflammation and fistula were significant risk factors for diverting ileostomy. The median proportion of sulfomucin-producing GCs on histological analysis of 82 pouch biopsies from 23 patients was 9.9% (range, 0%–93%). The duration of disease was significantly greater in the high HID group compared to the low HID group. The median percentage of sulfomucin-producing GCs was significantly higher in patients with diffuse inflammation or fistula compared to other endoscopic phenotypes (14% vs. 6.0%, <i>P</i>= 0.011).Conclusions: Greater proportions of sulfomucin-producing GCs were observed in endoscopic phenotypes associated with poor outcomes in UC, indicating patients with pouchitis showing colonic metaplasia of GCs may benefit from early interventions.
#Phenotype #Ulcerative colitis #Pouchitis #Sulfomucin: Goblet cells #Phenotype, Ulcerative colitis, Pouchitis, Sulfomucin #Goblet cells

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