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논문 기본 정보

자료유형
학술저널
저자정보
이동건 (서울대학교) 박승민 (서울대학교) 임창우 (서울대학교) 장동현 (서울대학교) 정우진 (연세대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal Vol.65 No.3
발행연도
2024.3
수록면
181 - 188 (8page)
DOI
10.3349/ymj.2023.0128

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Purpose: Previous studies have suggested that serum phosphate concentration is a prognostic factor in critically ill patients. How ever, the association between changes in serum phosphate levels and prognosis of patients with trauma remains unclear. Materials and Methods: This study included patients with severe trauma who were treated at the emergency department. Delta phosphate (Δ phosphate) was defined as the difference between serum phosphate concentrations measured at baseline and af ter 24 hours from the initial measurement. Patients were divided into five groups according to their Δ phosphate levels: group I (Δphosphate <-2 mg/dL), group II (Δ phosphate -2 to -0.5 mg/dL), group III (Δ phosphate -0.5 to 0.5 mg/dL), group IV (Δ phosphate 0.5 to 2 mg/dL), and group V (Δ phosphate ≥2 mg/dL). Results: Overall, 1905 patients with severe trauma were included in the analysis. The 30-day mortality was the lowest in group III and tended to increase in groups with a larger Δ phosphate in both the positive and negative directions (group I: 13.7%, group II: 6.8%, group III: 4.6%, group IV: 6.6%, and group V: 26.8%). In multivariable analysis with group III as the reference group, the odds ratios (ORs) of mortality were statistically significant in group IV [OR, 1.92; 95% confidence interval (CI), 1.05–3.56] and group V (OR, 5.28; 95% CI, 2.47–11.24). Conclusion: An increase in serum phosphate concentrations 24 hours after the initial measurement could be considered as an independent prognostic factor in patients with severe trauma.

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