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논문 기본 정보

자료유형
학술저널
저자정보
Tian Yanpeng (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Liu Yibin (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Xiao Yanlai (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Li Zhongkang (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Zhang Mingle (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Chen Liang (Department of Anesthesiology, The Fourth Hospital of Shijiazhuang) Li Zhen (Department of Anesthesiology, The Second Hospital of Hebei Medical University) Zhang Wangchao (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Zhang Zhiqiang (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Kong Desheng (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Meng Li (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Du Yanfang (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Zhang Jingkun (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University) Gao Jingui (Department of Anesthesiology, The Second Hospital of Hebei Medical University) Huang Xianghua (Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제21권 제2호
발행연도
2024.2
수록면
277 - 290 (14page)
DOI
10.1007/s13770-023-00604-2

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초록· 키워드

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Background: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a severe congenital disorder characterized by vaginal hypoplasia caused by dysplasia of the Müllerian duct. Patients with MRKH syndrome often require nonsurgical or surgical treatment to achieve satisfactory vaginal length and sexual outcomes. The extracellular matrix has been successfully used for vaginal reconstruction. Methods: In this study, we developed a new biological material derived from porcine vagina (acellular vaginal matrix, AVM) to reconstruct the vagina in Bama miniature pigs. The histological characteristics and efficacy of acellularization of AVM were evaluated, and AVM was subsequently transplanted into Bama miniature pigs to reconstruct the vaginas. Results: Macroscopic analysis showed that the neovaginas functioned well in all Bama miniature pigs with AVM implants. Histological analysis and electrophysiological evidence indicated that morphological and functional recovery was restored in normal vaginal tissues. Scanning electron microscopy showed that the neovaginas had mucosal folds characteristics of normal vagina. No significant differences were observed in the expression of CK14, HSP47, and α-actin between the neovaginas and normal vaginal tissues. However, the expression of estrogen receptor (ER) was significantly lower in the neovaginas than in normal vaginal tissues. In addition, AVM promoted the expression of β-catenin, c-Myc, and cyclin D1. These results suggest that AVM might promotes vaginal regeneration by activating the β-catenin/c-Myc/cyclin D1 pathway. Conclusion: This study reveals that porcine-derived AVM has potential application for vaginal regeneration.

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