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논문 기본 정보

자료유형
학술저널
저자정보
Jung-Kyeom Kim Sang-Won Park Suk-Hee Lee Payam Hosseinzadeh Kasani Gi Hwan Byeon Yeshin Kim Jae-Won Jang Seo-Young Lee
저널정보
대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology Vol.20 No.2
발행연도
2024.3
수록면
208 - 213 (6page)

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Background and Purpose The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures. Methods We reconstructed a population-based matched cohort from the National Health Insurance Service—Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea. Results Overall 53,776 subjects with lower-body fractures were identified during 2006–2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lowerbody fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49–1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14–1.23). Conclusions These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.

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