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논문 기본 정보

자료유형
학술저널
저자정보
Wang Mingzhu (Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. ChinaEngineering Research Center of North-East Cold Region Beef Cattle Science) Zhang Longzhou (Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. China) Piao Huiyan (Department of Chemistry, National Demonstration Centre for Experimental Chemistry Education, Yanbian University, Yanji, Jilin 133002, P.R. China) Jin Yuanming (Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. ChinaEngineering Research Center of North-East Cold Region Beef Cattle Science) Cui Chengdu (Department of Animal Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China) Jin Xin (Laboratory Animal Center?Yanbian University, Yanji, Jilin 133002, P.R. China) Cui Lianhua (Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. ChinaEngineering Research Center of North-East Cold Region Beef Cattle Science) Yan Chunri (Department of Preventive Medicine, Medical College, Yanbian University, Yanji, Jilin 133002, P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.3
발행연도
2024.3
수록면
689 - 699 (11page)
DOI
10.4014/jmb.2308.08056

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Colitis is a major gastrointestinal disease that threatens human health. In this study, a synbiotic composed of inulin and Pediococcus acidilactici (P. acidilactici) was investigated for its ability to alleviate dextran sulfate sodium (DSS)-induced colitis. The results revealed that the synbiotic, composed of inulin and P. acidilactici, attenuated the body weight loss and disease activity index (DAI) score in mice with DSS-mediated colitis. Determination of biochemical indicators found that the synbiotic increased anti-oxidation and alleviated inflammation in mice. Additionally, histopathological examination revealed that colonic goblet cell loss and severe mucosal damage in the model group were significantly reversed by the combination of inulin and P. acidilactici. Moreover, synbiotic treatment significantly reduced the levels of IL-1β, TNF-α, and IL-6 in the serum of mice. Thus, a synbiotic composed of inulin and P. acidilactici has preventive and therapeutic effects on DSSinduced colitis in mice.

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