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논문 기본 정보

자료유형
학술저널
저자정보
이나경 (Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea) Lee Yunjung (Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea) Shin Da-Soul (Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea) Ra Jehyeon (FM MI center, Daesang Wellife, Seoul 03130, Republic of Korea) Choi Yong-Min (FM MI center, Daesang Wellife, Seoul 03130, Republic of Korea) Ryu Byung Hee (Jongga R) Lee Jinhyeuk (FM MI center, Daesang Wellife, Seoul 03130, Republic of Korea) Park Eunju (Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea) Paik Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.2
발행연도
2024.2
수록면
399 - 406 (8page)
DOI
10.4014/jmb.2310.10026

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Lactiplantibacillus plantarum DSR330 (DSR330) has been examined for its antimicrobials production and probiotics. In this study, the hepatoprotective effects of DSR330 were examined against nonalcoholic fatty liver disease (NAFLD) in a high-fat diet (HFD)-fed C57BL/6 mouse model. To induce the development of fatty liver, a HFD was administered for five weeks, and then silymarin (positive control) or DSR330 (108 or 109 CFU/day) was administered along with the HFD for seven weeks. DSR330 significantly decreased body weight and altered serum and hepatic lipid profiles, including a reduction in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels compared to those in the HFD group. DSR330 significantly alleviated HFD-related hepatic injury by inducing morphological changes and reducing the levels of biomarkers, including AST, ALT, and ALP. Additionally, DSR330 alleviated the expression of SREBP-1c, ACC1, FAS, ACO, PPARα, and CPT-1 in liver cells. Insulin and leptin levels were decreased by DSR330 compared to those observed in the HFD group. However, adiponectin levels were increased, similar to those observed in the ND group. These results demonstrate that L. plantarum DSR330 inhibited HFD-induced hepatic steatosis in mice with NAFLD by modulating various signaling pathways. Hence, the use of probiotics can lead to hepatoprotective effects.

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