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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.29 No.2
- 발행연도
- 2024.6
- 수록면
- 154 - 161 (8page)
이용수
이 논문의 연구 히스토리 (5)
2021
Inhibitory Effect of Tilianin on Muscle Atrophy through the PI3K/Akt Pathway in C2C12 Myotubes
Yu Kyong Woo
,
Jae-Kwan Hwang
한국식품영양과학회 학술대회발표집
2021.10
학술대회자료
Agastache rugosa Kuntze Extract Attenuates Muscle Atrophy by Regulating the Protein Turnover and Differentiation in C2C12 Myotubes
Yu Kyong Woo
,
Jae-Kwan Hwang
한국식품영양과학회 학술대회발표집
2021.10
학술대회자료
A Mixture of Black Rice and Black Soybean Extract Attenuates Muscle Atrophy through the Regulation of Protein Turnover in Aged C57BL/6J Mice
Yu Kyong Woo
,
Hyunbin Jang
,
Hae Rim Kim
외 1명
한국식품영양과학회 학술대회발표집
2021.10
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Skeletal muscle atrophy, which is characterized by diminished muscle mass, strength, and function, is caused by malnutrition, physical inactivity, aging, and diseases. Korean mint (Agastache rugosa Kuntze) possesses various biological functions, including anti-inflammatory, antioxidant, anticancer, and antiosteoporosis activities. Moreover, it contains tilianin, which is a glycosylated flavone that exerts antioxidant, anti-inflammatory, antidiabetic, and neuroprotective activities. However, no studies have analyzed the inhibitory activity of A. rugosa extract (ARE) and tilianin on muscle atrophy. Thus, the present study investigated the potential of ARE and tilianin on muscle atrophy and their underlying mechanisms of action in C2C12 myotubes treated with tumor necrosis factor-α (TNF-α. The results showed that ARE and tilianin promoted the phosphatidylinositol 3-kinase/protein kinase B pathway, thereby activating mammalian target of rapamycin (a protein anabolism-related factor) and its downstream factors. Moreover, ARE and tilianin inhibited the mRNA expression of muscle RING-finger protein-1 and atrogin-1 (protein catabolism-related factors) by blocking Forkhead box class O₃ translocation. ARE and tilianin also mitigated inflammatory responses by downregulating nuclear factor-kappa B expression levels, thereby diminishing the expression levels of inflammatory cytokines, including TNF-α and interleukin-6. Additionally, ARE and tilianin enhanced the expression levels of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. Overall, these results suggest that ARE and tilianin are potential functional ingredients for preventing or improving muscle atrophy.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Inhibitory Effect of Tilianin on Muscle Atrophy through the PI3K/Akt Pathway in C2C12 Myotubes
한국식품영양과학회 학술대회발표집
2021 .10
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Analysis of essential oils by GC/MS and tilianin by HPLC/UV of the aerial parts of Agastache rugosa
Korean Journal of Agricultural Science
2023 .03
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단백질 대사 경로 조절을 통한 배초향 추출물과 틸리아닌의 부동화 유도 근위축 억제 효과
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Agastache rugosa Kuntze Extract Attenuates Muscle Atrophy by Regulating the Protein Turnover and Differentiation in C2C12 Myotubes
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2021 .10
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Anti-photoaging Effects of Agastache rugosa Extract and Its Active Compound Tilianin in Human Dermal Fibroblasts
한국식품영양과학회 학술대회발표집
2018 .10
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배초향(Agastache rugosa) 꽃의 발달단계에 따른 Acacetin, Tilianin, Rosmarinic acid 함량의 변화
한국원예학회 학술발표요지
2019 .05
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오존가스 처리에 의한 배초향(Agastache rugosa)의 Rosmarinic acid와 Tilianin, Acacetin 함량 증가
한국원예학회 학술발표요지
2016 .10
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배양액의 높은 EC와 메틸 자스모네이트 처리에 의한 배초향(Agastache rugosa )의 Tilianin과 Acacetin 함량 증가
한국원예학회 학술발표요지
2016 .05
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야파(night interruption)처리에 의한 배초향의 항산화 물질 증가
생물환경조절학회지
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A Mixture of Oryza sativa L. and Rhynchosia nulubilis Extract Inhibits Immobilization-induced Muscle Atrophy in C57BL/6J Mice through the Regulation of Protein Turnover
한국식품영양과학회 학술대회발표집
2021 .10
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Inhibitory Effect of Red Bean Extract on TNF-α-induced Muscle Atrophy in Skeletal Muscle Cells
한국식품영양과학회 학술대회발표집
2016 .10
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근위축 마우스 모델에서 한국산 겨우살이 추출물에 의한 단백질 합성 신호전달 경로의 활성화
한국식품영양학회지
2017 .04
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Nutraceutical potential of Peucedanum japonicum Thunb. for the prevention of muscle atrophy
한국식품영양과학회 학술대회발표집
2021 .10
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Influence of Root Cutting Time and Ratio on Growth and Accumulating Antioxidant in Agastache rugosa
한국원예학회 학술발표요지
2017 .10
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Herbal medicines to prevent skeletal muscle atrophy
한국식품영양과학회 학술대회발표집
2023 .10
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피부 건강을 위한 국내 자생 천연 식물 원료: AgatriⓇ (배초향 추출물)
식품과학과 산업
2020 .12
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C-peptide prevents Muscle Wasting in Dexamethasone-Induced Muscle Atrophy
한국식품영양과학회 학술대회발표집
2022 .10
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Inhibitory Effect of Sargassum fulvellum Extract on TNF-α-induced Muscle Atrophy in C2C12 Skeletal Muscle Cells
한국식품영양과학회 학술대회발표집
2016 .10
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Inhibitory Effect of Cudrania tricuspidata Leaf Extracts on Skeletal Muscle Atrophy through the PI3K/Akt Pathway in L6 Myotubes
한국식품영양과학회 학술대회발표집
2020 .10
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Amelioration of Muscle Wasting by C-Peptide in Glucocorticoid-Induced Skeletal Muscle Atrophy
한국식품영양과학회 학술대회발표집
2021 .10
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