지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 79 - 88 (10page)
- DOI
- 10.22889/KJP.2024.55.2.79
이용수
초록· 키워드
오류제보하기
Rhododendron mucronulatum has been used in folk remedies and traditional medicine to treat various diseases such as cold symptoms and inflammation. It has been reported through previous studies that this is caused by flavonoids, which constitute most of the secondary metabolites of plants of the genus Rhododendron and there was a study result that taxifolin glycosides were isolated from R. mucronulatum. R. mucronulatum has been studied for various activities such as antioxidant, antibacterial, and anti-inflammatory, but research on anti-hair loss activity is lacking. Therefore, in this study, taxifolin glycoside was isolated and purified from R. mucronulatum root extract, and after structural identification, anti-hair loss activity was studied. First, an experiment was conducted to suppress the production of dihydrotestosterone (DHT), which is the main cause of male pattern hair loss, and an experiment was conducted to suppress apoptosis of hair follicle dermal papilla cells (HFDPC) due to oxidative stress. As a result, both R. mucronulatum extract and taxifolin glycosides showed concentration-dependent manner DHT production inhibitory activity and apoptosis inhibitory activity at the total concentration of the experiment. In addition, it showed the activity of increasing the expression of IGF-1, a hair growth promoting factor, and decreasing the expression of, TGF-β1, a hair growth inhibitory factor. Therefore, the potential for development as a new material for the treatment of male pattern hair loss was confirmed.
목차
Abstract
Experimental
Results and Discussion
Conclusions
References
참고문헌 (26)
참고문헌 신청
Kim, G. B., Shin, K. S., Kim, C. M. and Kwon, Y. S. (2006) Flavonoids from the leaves of Rhododendron schlipenbachii. Kor. J. Parmacogn. 37: 177-183.
Korea National Arboretum (2021) Checklist of vascular plants in Korea (Native Plants).
Yuejiao, F., Luyan, Z. and Gang, C. (2012) Far infrared-assisted extraction followed by MEKC for the simultaneous determination of flavones and phenolic acids in the leaves of Rhododendron mucronulatum Turcz. J. Sep. Sci. 35: 468-475.
Naoki, I., Naili, W., Xinsheng, Y. and Susumu, K. (2004) Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. J. Nat. Prod. 67: 1106-1109.
Paleah, B., Ammar, S., Andrew, D., Jose, G. A., Brendan, W-R., Pierre, H., Alain, C. and John, T. A. (2011) Seasonal variation of phenolic constituents and medicinal activities of northern labrador tea, Rhododendron tomentosum ssp. subarcticum, an Inuit and Cree First Nations Traditional Medicine. Planta Med. 77: 1655-1662.
Korea National Arboretum (2021) Checklist of vascular plants in Korea (Native Plants).
Yuejiao, F., Luyan, Z. and Gang, C. (2012) Far infrared-assisted extraction followed by MEKC for the simultaneous determination of flavones and phenolic acids in the leaves of Rhododendron mucronulatum Turcz. J. Sep. Sci. 35: 468-475.
Naoki, I., Naili, W., Xinsheng, Y. and Susumu, K. (2004) Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. J. Nat. Prod. 67: 1106-1109.
Paleah, B., Ammar, S., Andrew, D., Jose, G. A., Brendan, W-R., Pierre, H., Alain, C. and John, T. A. (2011) Seasonal variation of phenolic constituents and medicinal activities of northern labrador tea, Rhododendron tomentosum ssp. subarcticum, an Inuit and Cree First Nations Traditional Medicine. Planta Med. 77: 1655-1662.
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