지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 135 - 142 (8page)
- DOI
- 10.20307/nps.2024.30.2.135
이용수
초록· 키워드
오류제보하기
As part of our current projects to discover biologically active compounds from natural sources, we conducted a phytochemical investigation of Juncus decipiens, a species generally distributed throughout Korea. J. decipiens has been used in traditional Chinese medicine to control diuresis for strangury and clear out heart fire. The phytochemical investigation of the EtOH extract of J. decipiens led to the isolation of five phenolic compounds (1–5) via semi-preparative HPLC purification. The chemical structures of the isolated compounds were identified as isosaponarin (1), isovitexin 7,2′′-di-O-glucoside (2), 4-O-feruloylquinic acid (3), 5-O-feruloylquinic acid (4), and 3-O-caffeoylquinic acid (5) based on comparisons of their spectroscopic and physical properties with those reported in previous studies. Notably, this is the first report of the presence of compounds (1–4) in J. decipiens. Then, compounds 1–5 were tested to determine their effects on osteogenesis and adipogenesis in the mouse mesenchymal stem cell line C3H10T1/2. We found that quinic acid derivatives (3–5) promoted the osteogenic differentiation of stem cells. These findings demonstrate that the bioactive quinic acid derivatives might be effective for the treatment of menopause-associated syndromes, such as osteoporosis, as the isolated compounds were shown to promote osteogenesis of stem cells.
목차
Abstract
Introduction
Experimental
Results and Discussions
References
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