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Fucoidan, one of the dominant sulfated polysaccharides extracted from brown seaweed, possesses a wide range of biological activities. Transforming growth factor-β (TGF-β) plays a pivotal role in the pathogenesis of pulmo nary fibrosis, by stimulating the synthesis of profibrotic factors. In this study, we investigated the in vitro effects of fucoidan on collagen synthesis, α-smooth muscle actin (α-SMA) expression, and interleukin (IL)-6 production in TGF-β-stimulated human pulmonary fibroblasts. The expression of type I collagen and α-SMA was detected by Western blot, and the production of IL-6 by enzyme-linked immunosorbent assay. TGF-β1 treatment of pulmonary fibroblasts enhanced the expression of α-SMA, type I collagen, and IL-6 whereas these effects were inhibited in cells pretreated with fucoidan. The activation of Smad2/3, p38 mitogen-activated protein kinases (MAPKs), and Akt was also inhibited in fucoidan-pretreated, TGF-β1-stimulated human pulmonary fibroblasts. These data demonstrate the anti-fibrotic potential of fucoidan in TGF-β-induced human pulmonary fibroblasts, via the inhibition of Smad2/3, p38 MAPKs, and Akt phosphorylation. Our results suggest the therapeutic potential of fucoidan in the prevention or treatment of pulmonary fibrosis.
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Turbinaria ornata, a source of fucoidan; Purified fucoidan abate LPS-induced inflammatory responses in in-vitro and in-vivo models
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The Anti-aging effects of fucoidan-rich polysaccharides extracted from Sargassum horneri
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Exploring the Anti-Inflammatory Potential and Structural Features of Fucoidan Extracted from Ecklonia maxima Stipe
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Protective Activity of Ginseng seed against UVB-induced Photoaging via Modulation of TGF-β/Smad and MAPK/AP-1 in Human Skin Fibroblasts
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Anti-wrinkling activity of a fucoidan isolated from Undaria pinnatifida
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Functionality study of fucoidan in the improvement of fatty liver in NAFLD-induced liver cells
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Anti-inflammatory activity of fucoidan extracted from brown alga Ecklonia maxima Leaves in particulate matter-stimulated RAW 264.7 Macrophage cells
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Fucoidan Derived from Brown Algae Ameliorates AAPH-induced Oxidative Stress in vitro and in vivo
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다시마 fucoidan, alginate, fucoxanthin의 분리 및 특성
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