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논문 기본 정보

자료유형
학술저널
저자정보
Merrah Joy Blaya Subebe (MSU-Iligan Institute of Technology) Josephine C. Ogaro (MSU-Iligan Institute of Technology) Melanie L. Dayon (MSU-Iligan Institute of Technology) Muhmin Michael E. Manting (MSU-Iligan Institute of Technology) Aki Murashima (Gifu Pharmaceutical University) Akiko Omori (University of Padova) Jaime Q. Guihawan (MSU-Iligan Institute of Technology) Mylene M. Uy (MSU-Iligan Institute of Technology) Ahmad Reza F. Mazahery (University of the Philippines) Mylah Villacorte-Tabelin (MSU-Iligan Institute of Technology)
저널정보
환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.39 No.1
발행연도
2024.3
수록면
37 - 51 (15page)

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Decalobanthus peltatus is a woody vine that is commonly utilized in traditional Southeast Asian medicinal preparations. Despite the documented therapeutic uses of D. peltatus, there is hardly any information regarding its toxic effects on its consumers. In this study, crude leaf extracts (aqueous, methanol, ethyl acetate, and hexane) from D. peltatus were prepared and evaluated for their embryotoxicity and teratogenic effects. Phytochemical screening of bioactive compounds from the plants showed the presence of alkaloids, flavonoids, saponins, steroids, and tannins. In addition, investigations on the toxicity of the crude leaf extracts were determined using brine shrimp lethality assay, in which the LC50 was calculated. Results showed that the ethyl acetate leaf extract was the most toxic among the crude leaf extracts, with an LC50 of 14.54 ppm. Based on this result, ethyl acetate leaf extract was treated on duck embryos, and the alteration of vascular branching patterns in the chorioallantoic membrane was quantified. Gross morphological and histological analysis of the skin tissues from the treated duck embryos were also examined. We found significant reduction of primary and tertiary vessel diameters in the duck embryos treated with ethyl acetate leaf extracts in both concentrations compared to the control group. Treated duck embryos exhibited gross malformations, growth retardation, and hemorrhages on the external body surfaces at 1000 ppm. Histopathological analysis of the skin tissues from the 14-day-old treated duck embryos showed a reduced number of feather follicles compared to the control group. These results suggest that D. peltatus crude leaf extracts present risks when taken in significant dosages and comprehensive toxicity testing on therapeutic herbs should be performed to ensure their safety on the consumers.
#CAM assay #Decalobanthus peltatus #embryo malformations #embryotoxic #medicinal plants #teratogenic

목차

Introduction
Materials and Methods
Results and Discussion
Conclusions
References

참고문헌 (65)

참고문헌 신청
Alafiatayo AA, Lai KS, Syahida A, Mahmood M, Shaharuddin NA. Phytochemical evaluation, embryotoxicity, and teratogenic effects of Curcuma longa extract on zebrafish (Danio rerio). Evid Based Complement Alternat Med 2019;2019:3807207. https://doi.org/10.1155/2019/3807207 google schola Pě sí c M. Development of natural product drugs in a sustainable manner. [cited Jul 11, 2023]. Available from: https://sustainabledevelopment.un.org/content/documents/6544118_Pesic_Development%20of%20natural%20product%20drugs%20in%20a%20%20sustainable%20manner.pdf google schola Fitzgerald M, Heinrich M, Booker A. Medicinal plant analysis: a historical and regional discussion of emergent complex techniques. Front Pharmacol 2019;10:1480. https://doi.org/10.3389/fphar.2019.01480 google schola Mujeeb F, Bajpai P, Pathak N. Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. Biomed Res Int 2014;2014:497606. https://doi.org/10.1155/2014/497606 google schola Ali S, Khan MR, Irfanullah, Sajid M, Zahra Z. Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder. BMC Complement Altern Med 2018;18:43. https://doi.org/10.1186/s12906-018-2114-z google schola

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