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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.39 No.1
- 발행연도
- 2024.3
- 수록면
- 1 - 15 (15page)
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초록· 키워드
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Breast and hepatic cancers are the leading incidences in the globe occurring of the human sufferings from various cancers. Snake venoms have been reported to provide effective therapeutic agents. The current study investigates the anticancer potency of Egyptian venoms snakes on two cells: breast cancer cells (MCF-7) and hepato-cancer cells (HepG2) (In vitro assay). The examined venoms were more potent on MCF-7 than HepG2 cells. Their inhibition % on MCF-7 ranged from 71.47 to 99.02% with medium inhibition concentrations (IC50s): 3.48, 3.60, 3.70, 4.33, and 4.49 μg/ml for venoms: Echis pyramid (E.H), Cerastes vipera (C.V), Naja haje (N.H), Echis coloratus (E.C), and Cerastes cerastes (C.C), respectively. The values of IC50s on HepG2 were 4.32, 17.77, 59.72, 63.75, and 217.90 μg/ml for toxins: E.C, E.P, C.V, C.C, and N.H, respectively. Some biomarkers were conducted to investigate the apoptotic effects of toxins into the cells. Increasing profiles of lactate dehydrogenase (LDH) activity and levels of glutathione content (GSH) and malodialdhyde (MDA) as well as repairment of DNA indicated such these actions. So, more reliable investigations on these venoms were needed to provide intelligent therapeutic agent for cancer treatment.
목차
Abstract
Introduction
Materials and Methods
Cell Lines
Results
Discussion
Conclusions
References
참고문헌 (60)
참고문헌 신청
Roy A, Jauhari N, Bharadvaja N. Medicinal plants as a potential source of chemopreventive agents. In: Akhtar, M., Swamy, M, editors. Anticancer Plants: Natural Products and Biotechnological Implements. Springer; 2018. 109-139.
Abidin SAZ, Lee YQ, Othman I, Naidu R. Malaysian cobra venom: A potential source of anti-cancer therapeutic agents. Toxins (Basel) 2019;11(2):75. https://doi.org/10.3390/toxins11020075
Jackson K. The evolution of venom-delivery systems in snakes. Zoological Journal of the Linnean Society 2003;137(3):337-354. https://doi.org/10.1046/j.1096-3642.2003.00052.x
Al Asmari AK, Khan HA, Manthiri RA, Al Yahya KM, Al Otaibi KE. Effects of Echis pyramidum snake venom on hepatic and renal antioxidant enzymes and lipid peroxidation in rats. J Biochem Mol Toxicol 2014;28(9):407-412. https://doi.org/10.1002/jbt.21578
Hofmann EP, Rautsaw RM, Strickland JL, Holding ML, Hogan MP, Mason AJ, et al. Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression despite individual variation. Sci Rep 2018;8:15534. https://doi.org/10.1038/s41598-018-33943-5
Abidin SAZ, Lee YQ, Othman I, Naidu R. Malaysian cobra venom: A potential source of anti-cancer therapeutic agents. Toxins (Basel) 2019;11(2):75. https://doi.org/10.3390/toxins11020075
Jackson K. The evolution of venom-delivery systems in snakes. Zoological Journal of the Linnean Society 2003;137(3):337-354. https://doi.org/10.1046/j.1096-3642.2003.00052.x
Al Asmari AK, Khan HA, Manthiri RA, Al Yahya KM, Al Otaibi KE. Effects of Echis pyramidum snake venom on hepatic and renal antioxidant enzymes and lipid peroxidation in rats. J Biochem Mol Toxicol 2014;28(9):407-412. https://doi.org/10.1002/jbt.21578
Hofmann EP, Rautsaw RM, Strickland JL, Holding ML, Hogan MP, Mason AJ, et al. Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression despite individual variation. Sci Rep 2018;8:15534. https://doi.org/10.1038/s41598-018-33943-5
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