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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.3
- 수록면
- 47 - 53 (7page)
- DOI
- 10.22889/KJP.2024.55.1.47
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해당 논문이 위치하는 상위 비율을 의미합니다.
초록· 키워드
오류제보하기
Parkinson’s disease (PD), the second most prevalent neurodegenerative disease after Alzheimer"s, is marked by progressive loss of dopaminergic (DA) neurons in the substantia nigra. Although drugs like levodopa, selegiline, and amantadine offer symptomatic relief, they fail to address the underlying cause of PD. In this study, we explored the neuroprotective potential of Prunus padus methanolic extract (PPE) using the Caenorhabditis elegans model system. Our results demonstrate that PPE treatment significantly mitigated MPP+-induced morphological defects in DA neurons. Similarly, PPE-fed mutant worms overexpressing tyrosine hydroxylase showed reduced damage to DA neurons. In addition, the food-sensing ability of worms was ameliorated by PPE supplementation under MPP+ exposure conditions, suggesting its potential for the functional restoration of DA neurons. PPE also has the ability to down-regulate the formation of α-synuclein oligomers and fibrils in mutant worms expressing human α-synuclein. Moreover, under conditions of tunicamycin-induced endoplasmic reticulum stress, PPE treatment attenuated hsp-4 expression, indicating its role in preserving protein homeostasis. Overall, our findings suggest that P. padus has strong neuroprotective properties and may be a promising drug candidate for PD therapy.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (30)
참고문헌 신청
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. and Seitelberger, F. (1973) Brain dopamine and the syndromes of Parkinson and huntington clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20: 415-455.
Liu, J., Banskota, A. H., Critchley, A. T., Hafting, J. and Prithiviraj, B. (2015) Neuroprotective effects of the cultivated Chondrus crispus in a C. elegans model of Parkinson's disease. Mar. Drugs 13: 2250-2266.
Marvanova, M. and Nichols, C. D. (2007) Identification of neuroprotective compounds of Caenorhabditis elegans dopaminergic neurons against 6-OHDA. J. Mol. Neurosci. 31: 127-137.
van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W, Plasterk, R. H. A. and Nollen, E. A. A. (2008) C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet. 4: e1000027.
Nass, R., Hall, D. H., Miller, D. M. and Blakely, R. D. (2002) Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 99: 3264-3269.
Liu, J., Banskota, A. H., Critchley, A. T., Hafting, J. and Prithiviraj, B. (2015) Neuroprotective effects of the cultivated Chondrus crispus in a C. elegans model of Parkinson's disease. Mar. Drugs 13: 2250-2266.
Marvanova, M. and Nichols, C. D. (2007) Identification of neuroprotective compounds of Caenorhabditis elegans dopaminergic neurons against 6-OHDA. J. Mol. Neurosci. 31: 127-137.
van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W, Plasterk, R. H. A. and Nollen, E. A. A. (2008) C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet. 4: e1000027.
Nass, R., Hall, D. H., Miller, D. M. and Blakely, R. D. (2002) Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 99: 3264-3269.
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