지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.8
- 수록면
- 82 - 94 (13page)
- DOI
- 10.35131/ishb.2023.17.2.82
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This study aims to assess the anti-oxidant, anti-inflammatory, and anti-microbial effects of Suaeda australis, which is known as halophytes. Methanol extracts of S. australis were fractioned according to the polarity with n-hexane, chloroform, ethyl acetate, n-butanol, and H2O. The anti-oxide activity of the fractions was evaluated using DPPH radical scavenging activity and total polyphenol content. All solvent fractions showed potent anti-oxidative effects, as assessed using radical scavenging activity, with IC50 values ranging from 109.782 to 754.691 ㎍/mL. In agreement with this pattern, the total phenolic contents were widely distributed in solvent fractions, and ranged from 10.746 to 50.672 mg/g GAE of dry weight. In the evaluation of anti-inflammatory effects, LPS-activated RAW264.7 macrophages suppressed the expression of iNOS and COX-2, as well as the production of TNF-α and IL-6. Skin barrier protective effects were investigated in HaCaT cells measuring the mRNA expression of skin barrier integrity and hydration genes, namely, HBD (human β-defensin), LL-37(cathelicidin), and HAS (hyaluronic acid synthase). The ethyl acetate fraction showed the strongest skin barrier integrity. Based on the current results, S. australis was suggested to posses natural anti-oxidant and anti-inflammatory agents, and skin protective materials, indicating that it could be a valuable source of multi-functional cosmetic ingredients.
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