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논문 기본 정보

자료유형
학술저널
저자정보
장흔이 (서경대학교) 이지안 (서경대학교)
저널정보
한국화장품미용학회 한국화장품미용학회지 한국화장품미용학회지 제13권 3호
발행연도
2023.12
수록면
477 - 485 (9page)

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초록· 키워드

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Osmanthus fragrans, the genus Osmanthus in the family of Oleaceae, is distributed in China, Japan and southern area of Korea. Especially, O. fragrans var. auranthiacus Makino(OFM) was reported to contain antioxidant, anti-inflammatory, anti-melanin, and anti-cancer effects. Howe ver, there is limited information about the O. fragrans var. latifolius(OFL)"s potential bioactivities. The present study evaluated the antioxidant, anti-inflammatory, anti-wrinkle, and whitening activities of polar(ethanol and hot-water) extracts from OFM and OFL leaves. All extracts show ed 2,2-diphenyl-1-picrylhydrazyl(DPPH) anion radical and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS) cation radical scavenging g activities in a concentration-dependent manner and OFL ethanol extract(LE) exhibited the highest of total polyphenolic contents(90.108±1.624). The significant cytotoxicity was not observed up to a concentration of 0.5 mg/mL in mouse macrophage cells(RAW264.7), normal human dermal fibroblast(NHDF), and mouse melanoma (B16F10) cells. In LPS-induced RAW264.7 cells, LE and OFM ethanol extract(ME) significantly reduced NO production, inducible nitric oxide(iNOS) protein expression and downregulated proinflammatory cytokines such as interleukin(IL)-6 and tumor necrosis factor(TNF)-α. OFL hot-water extract(LD) was also decreased the generation of MMP(matrix metalloproteinase)-1 protein in NHDF cells. In addition, LE inhibited in vitro tyrosinase activity and melanin production induced by α-MSH in B16F10 cells. Taken together, the O. fragrans var. latifolius leaves is expected to have a value as an excellent anti-aging ingredient for functional cosmetics.

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ABSTRACT
I 서론
II 실험방법
III 결과 및 고찰
IV. 결론
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