지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.9
- 수록면
- 188 - 193 (6page)
이용수
초록· 키워드
오류제보하기
Obesity is well known as a metabolic abnormality and potentially life-threatening condition associated with several chronic diseases. Various peptide drugs have been developed to treat obesity. In this study, optimization of expression conditions were performed to produce glucagon-like peptide-1 (GLP-1), which is used as an obesity treatment in recombinant E. coli. After the construction of expression vector system and optimization of expression conditions, the productivity of GLP-1 was increased to 11.18 mg/L·h in flask cultivation. Through fermentation conditions were optimized for bioreactor, the GLP-1 productivity was increased to 16.80 mg/L·h in bioreactor, which was 50.27% improvement as compared to the flask cultivation. When 1.00 mM lactose was used as an inducer instead of IPTG, 17.39% higher expression was shown than that with 0.01 mM IPTG.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Optimization of Induction Conditions for the Production of Recombinant Glucagon-like Peptide-1 in Escherichia coli
한국생물공학회 학술대회
2022 .09
-
재조합 대장균을 이용한 전달 단백질 rCRM197 생산
KSBB Journal
2018 .03
-
Improvement of Production of Recombinant Proteins in Rice Expression Systems by Using Various Signal Peptides
한국생물공학회 학술대회
2020 .06
-
Peptides as multifunctional players in cancer therapy
Experimental and Molecular Medicine
2023 .06
-
Stable and Effective Antimicrobial Peptide Delivery System by Self-entrapping Antimicrobial Peptides in Silica Particles
한국생물공학회 학술대회
2024 .09
-
Microbial Synthesis of Diverse Nanomaterials Using Recombinant Escherichia coli
한국생물공학회 학술대회
2020 .06
-
A Study on the Optimization of Recombinant Protein Expression Using Plant
한국생물공학회 학술대회
2023 .04
-
Design and Synthesis of Multifunctional Hybrid Peptides against Pathogenic Microbes
한국생물공학회 학술대회
2024 .09
-
Intrinsically Disordered peptides for self-encapsulation and controlled release of recombinant proteins
한국생물공학회 학술대회
2019 .10
-
Enhanced Gene Knockdown through Fusion Peptide-mediated siRNA Delivery
한국생물공학회 학술대회
2018 .04
-
Polymer-Based Delivery of Peptide Drugs to Treat Diabetes: Normalizing Hyperglycemia and Preventing Diabetic Complications
BioChip Journal
2022 .06
-
Novel silica forming peptides for the sustained release of recombinant proteins
한국생물공학회 학술대회
2019 .04
-
코돈 최적화된 유전자를 이용한 재조합 대장균으로부터 인간 인터페론 베타 발현
KSBB Journal
2017 .03
-
Optimization of the Fed-batch Culture of Recombinant Escherichia coli to Maximize the GABA Production
한국생물공학회 학술대회
2023 .10
-
Dual Padlock GLP1 Gene Delivery System to Treat Type 2 Diabetes Mellitus: One-week Glucose Level Control with a Single Dose
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Construction of Pesticides Recovering Escherichia coli through the Cell Surface Display of Binding Peptide
한국생물공학회 학술대회
2022 .04
-
H-1, C-13, and N-15 resonance assignments of ENOD40B, a plant peptide hormone
Journal of the Korean Magnetic Resonance Society
2023 .06
-
Soluble Expression of Recombinant Dengue Viral Non-structural Protein 1 in E.coli
한국생물공학회 학술대회
2023 .10
-
Newly Identified Partial Peptide Derived from Human Neutrophil Peptide-1 Promotes Hemostasis
한국생물공학회 학술대회
2019 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-24-02-088247512