Comparison of the effect of dexmedetomidine and midazolam under spinal anesthesia for cesarean delivery: a randomized controlled trial, single center study in South Korea

Kang Hyoseok; Lim Taeha; Lee Hyun jeong; Kim Tae Wan; Kim Wan; Chang Hae Wone

doi:10.17085/apm.22257

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자료유형: 학술저널

저자정보: Kang Hyoseok (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea) Lim Taeha (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea) Lee Hyun jeong (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea) Kim Tae Wan (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea) Kim Wan (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea) Chang Hae Wone (Department of Anesthesiology and Pain Medicine Nowon Eulji University Hospital Seoul Korea)

저널정보: 대한마취통증의학회(구 대한마취과학회) Anesthesia and Pain Medicine Anesthesia and Pain Medicine Vol.18 No.2

발행연도: 2023.4

수록면: 159 - 168 (10page)

DOI: 10.17085/apm.22257

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Background: Cesarean section under spinal anesthesia may cause anxiety and hypotension. Administration of sedative drugs after delivery can diminish these side-effects, but may increase hemodynamic instability. We evaluated the effect of the administration of 0.7 μg/kg dexmedetomidine and compared it with that of 0.03 mg/kg midazolam for usefulness of sedation of the parturient after delivery during cesarean section.Methods: After obtaining written consent and the ethics board approval, 60 parturients aged 20–43 years who underwent elective cesarean delivery under spinal anesthesia were recruited. A total of 0.5% hyperbaric bupivacaine (8–10 mg) and intrathecal fentanyl (10 μg) was given to induce anesthesia. Parturients were then randomly allocated to receive either midazolam (0.03 mg/kg; group M) or dexmedetomidine 0.7 (μg/kg; group D) after delivery. The primary outcome measure was patient satisfaction score. Secondary outcomes included vital signs; vasopressor dosage; incidence of shivering, nausea, and vomiting; incidence of bradycardia; time to sensory and motor recovery; postoperative nausea and vomiting score; and postoperative pain visual analog scale at 6, 24, and 48 h.Results: Satisfaction scores for sedation were similar between the two groups. The systolic blood pressure, heart rate, oximetry saturation, and tympanic temperature were comparable between the two groups. The predicted mean systolic blood pressure of group D was 106.3 mmHg and that of group M was 107.5 mmHg. Both groups showed comparable adverse intraoperative and postoperative outcomes.Conclusions: Dexmedetomidine and midazolam showed similar hemodynamic effects and patient satisfaction in parturients under spinal anesthesia.

#Cesarean section #Dexmedetomidine #Midazolam #Spinal anesthesia

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